Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)

Förster K, Marchi H, Stöcklein S, Dietrich O, Ehrhardt H, Wielpütz MO, Flemmer AW, Schubert B, Mall MA, Ertl-Wagner B, Hilgendorff A (2023)
American Journal of Physiology-Lung Cellular and Molecular Physiology 324(2): L114-L122.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Förster, Kai; Marchi, HannahUniBi ; Stöcklein, Sophia; Dietrich, Olaf; Ehrhardt, Harald; Wielpütz, Mark O.; Flemmer, Andreas W.; Schubert, Benjamin; Mall, Marcus A.; Ertl-Wagner, Birgit; Hilgendorff, Anne
Abstract / Bemerkung
Neonatal chronic lung disease lacks standardized assessment of lung structural changes. We addressed this clinical need by the development of a novel scoring system [UNSEAL BPD (UNiforme Scoring of the disEAsed Lung in BPD)] using T2-weighted single-shot fast-spin-echo sequences from 3 T MRI in very premature infants with and without bronchopulmonary dysplasia (BPD). Quantification of interstitial and airway remodeling, emphysematous changes, and ventilation inhomogeneity was achieved by consensus scoring on a five-point Likert scale. We successfully identified moderate and severe disease by logistic regression [area under the curve (AUC), 0.89] complemented by classification tree analysis revealing gestational age-specific structural changes. We demonstrated substantial interreader reproducibility (weighted Cohen’s κ 0.69) and disease specificity (AUC = 0.91). Our novel MRI score enables the standardized assessment of disease-characteristic structural changes in the preterm lung exhibiting significant potential as a quantifiable endpoint in early intervention clinical trials and long-term disease monitoring.
Erscheinungsjahr
2023
Zeitschriftentitel
American Journal of Physiology-Lung Cellular and Molecular Physiology
Band
324
Ausgabe
2
Seite(n)
L114-L122
ISSN
1040-0605
eISSN
1522-1504
Page URI
https://pub.uni-bielefeld.de/record/2968296

Zitieren

Förster K, Marchi H, Stöcklein S, et al. Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD). American Journal of Physiology-Lung Cellular and Molecular Physiology. 2023;324(2):L114-L122.
Förster, K., Marchi, H., Stöcklein, S., Dietrich, O., Ehrhardt, H., Wielpütz, M. O., Flemmer, A. W., et al. (2023). Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD). American Journal of Physiology-Lung Cellular and Molecular Physiology, 324(2), L114-L122. https://doi.org/10.1152/ajplung.00430.2021
Förster, Kai, Marchi, Hannah, Stöcklein, Sophia, Dietrich, Olaf, Ehrhardt, Harald, Wielpütz, Mark O., Flemmer, Andreas W., et al. 2023. “Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)”. American Journal of Physiology-Lung Cellular and Molecular Physiology 324 (2): L114-L122.
Förster, K., Marchi, H., Stöcklein, S., Dietrich, O., Ehrhardt, H., Wielpütz, M. O., Flemmer, A. W., Schubert, B., Mall, M. A., Ertl-Wagner, B., et al. (2023). Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD). American Journal of Physiology-Lung Cellular and Molecular Physiology 324, L114-L122.
Förster, K., et al., 2023. Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD). American Journal of Physiology-Lung Cellular and Molecular Physiology, 324(2), p L114-L122.
K. Förster, et al., “Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)”, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 324, 2023, pp. L114-L122.
Förster, K., Marchi, H., Stöcklein, S., Dietrich, O., Ehrhardt, H., Wielpütz, M.O., Flemmer, A.W., Schubert, B., Mall, M.A., Ertl-Wagner, B., Hilgendorff, A.: Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD). American Journal of Physiology-Lung Cellular and Molecular Physiology. 324, L114-L122 (2023).
Förster, Kai, Marchi, Hannah, Stöcklein, Sophia, Dietrich, Olaf, Ehrhardt, Harald, Wielpütz, Mark O., Flemmer, Andreas W., Schubert, Benjamin, Mall, Marcus A., Ertl-Wagner, Birgit, and Hilgendorff, Anne. “Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)”. American Journal of Physiology-Lung Cellular and Molecular Physiology 324.2 (2023): L114-L122.

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