The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues

Höving AL, Schmidt KE, Kaltschmidt B, Kaltschmidt C, Knabbe C (2022)
International Journal of Molecular Sciences 23(17): 9626.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 1.06 MB
Autor*in
Höving, Anna L.; Schmidt, Kazuko E.; Kaltschmidt, BarbaraUniBi; Kaltschmidt, ChristianUniBi; Knabbe, Cornelius
Abstract / Bemerkung
Tissue regeneration substantially relies on the functionality of tissue-resident endogenous adult stem cell populations. However, during aging, a progressive decline in organ function and regenerative capacities impedes endogenous repair processes. Especially the adult human heart is considered as an organ with generally low regenerative capacities. Interestingly, beneficial effects of systemic factors carried by young blood have been described in diverse organs including the heart, brain and skeletal muscle of the murine system. Thus, the interest in young blood or blood components as potential therapeutic agents to target age-associated malignancies led to a wide range of preclinical and clinical research. However, the translation of promising results from the murine to the human system remains difficult. Likewise, the establishment of adequate cellular models could help to study the effects of human blood plasma on the regeneration of human tissues and particularly the heart. Facing this challenge, this review describes the current knowledge of blood plasma-mediated protection and regeneration of aging tissues. The current status of preclinical and clinical research examining blood borne factors that act in stem cell-based tissue maintenance and regeneration is summarized. Further, examples of cellular model systems for a more detailed examination of selected regulatory pathways are presented.
Erscheinungsjahr
2022
Zeitschriftentitel
International Journal of Molecular Sciences
Band
23
Ausgabe
17
Art.-Nr.
9626
eISSN
1422-0067
Page URI
https://pub.uni-bielefeld.de/record/2965673

Zitieren

Höving AL, Schmidt KE, Kaltschmidt B, Kaltschmidt C, Knabbe C. The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues. International Journal of Molecular Sciences. 2022;23(17): 9626.
Höving, A. L., Schmidt, K. E., Kaltschmidt, B., Kaltschmidt, C., & Knabbe, C. (2022). The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues. International Journal of Molecular Sciences, 23(17), 9626. https://doi.org/10.3390/ijms23179626
Höving, Anna L., Schmidt, Kazuko E., Kaltschmidt, Barbara, Kaltschmidt, Christian, and Knabbe, Cornelius. 2022. “The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues”. International Journal of Molecular Sciences 23 (17): 9626.
Höving, A. L., Schmidt, K. E., Kaltschmidt, B., Kaltschmidt, C., and Knabbe, C. (2022). The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues. International Journal of Molecular Sciences 23:9626.
Höving, A.L., et al., 2022. The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues. International Journal of Molecular Sciences, 23(17): 9626.
A.L. Höving, et al., “The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues”, International Journal of Molecular Sciences, vol. 23, 2022, : 9626.
Höving, A.L., Schmidt, K.E., Kaltschmidt, B., Kaltschmidt, C., Knabbe, C.: The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues. International Journal of Molecular Sciences. 23, : 9626 (2022).
Höving, Anna L., Schmidt, Kazuko E., Kaltschmidt, Barbara, Kaltschmidt, Christian, and Knabbe, Cornelius. “The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues”. International Journal of Molecular Sciences 23.17 (2022): 9626.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0):
Volltext(e)
Name
Access Level
OA Open Access
Zuletzt Hochgeladen
2022-11-10T16:45:36Z
MD5 Prüfsumme
03d5eddf87569ca6fa0d2373f7a84af7


Link(s) zu Volltext(en)
Access Level
OA Open Access

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 36077021
PubMed | Europe PMC

Suchen in

Google Scholar