Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells
Zucker T-P, Bönisch D, Hasse A, Grosser T, Weber A-A, Schrör K (1998)
European Journal of Pharmacology 345(2): 213-220.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Zucker, Tom-Philipp;
Bönisch, Detlef;
Hasse, Andreas;
Grosser, TiloUniBi
;
Weber, Artur-Aron;
Schrör, Karsten
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Abstract / Bemerkung
This study compares the antimitogenic effects of iloprost and prostaglandin E1 on platelet-derived growth factor-BB stimulated DNA synthesis ([3H]thymidine incorporation) in bovine coronary artery smooth muscle cells. When added 20–24 h after stimulation with platelet-derived growth factor-BB (20 ng/ml), both iloprost and prostaglandin E1, concentration-dependently (IC50 3–5 nM) inhibited DNA synthesis. However, when added together with the growth factor (0–24 h), the inhibition of DNA synthesis by iloprost was markedly attenuated, indicating tolerance development. In contrast, no tolerance to antimitogenic effects of prostaglandin E1 or forskolin were observed. When added to iloprost-tolerant cells, both prostaglandin E1 and forskolin, still inhibited DNA synthesis. There was no evidence for transcriptional down-regulation of prostacyclin receptor gene by iloprost. The data demonstrate a tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 and suggest that the receptors, mediating the antiproliferative actions of these prostaglandins, may be different.
Erscheinungsjahr
1998
Zeitschriftentitel
European Journal of Pharmacology
Band
345
Ausgabe
2
Seite(n)
213-220
ISSN
00142999
Page URI
https://pub.uni-bielefeld.de/record/2965357
Zitieren
Zucker T-P, Bönisch D, Hasse A, Grosser T, Weber A-A, Schrör K. Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells. European Journal of Pharmacology. 1998;345(2):213-220.
Zucker, T. - P., Bönisch, D., Hasse, A., Grosser, T., Weber, A. - A., & Schrör, K. (1998). Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells. European Journal of Pharmacology, 345(2), 213-220. https://doi.org/10.1016/S0014-2999(98)00022-3
Zucker, Tom-Philipp, Bönisch, Detlef, Hasse, Andreas, Grosser, Tilo, Weber, Artur-Aron, and Schrör, Karsten. 1998. “Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells”. European Journal of Pharmacology 345 (2): 213-220.
Zucker, T. - P., Bönisch, D., Hasse, A., Grosser, T., Weber, A. - A., and Schrör, K. (1998). Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells. European Journal of Pharmacology 345, 213-220.
Zucker, T.-P., et al., 1998. Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells. European Journal of Pharmacology, 345(2), p 213-220.
T.-P. Zucker, et al., “Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells”, European Journal of Pharmacology, vol. 345, 1998, pp. 213-220.
Zucker, T.-P., Bönisch, D., Hasse, A., Grosser, T., Weber, A.-A., Schrör, K.: Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells. European Journal of Pharmacology. 345, 213-220 (1998).
Zucker, Tom-Philipp, Bönisch, Detlef, Hasse, Andreas, Grosser, Tilo, Weber, Artur-Aron, and Schrör, Karsten. “Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells”. European Journal of Pharmacology 345.2 (1998): 213-220.
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