Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model
Zacharowski K, Schneidmüller D, Ibe W, Grosser T, Buerke M, Meyer J, Darius H (2000)
British Journal of Pharmacology 129(3): 566-572.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Zacharowski, Kai;
Schneidmüller, Dorien;
Ibe, Waltraut;
Grosser, TiloUniBi
;
Buerke, Michael;
Meyer, Jürgen;
Darius, Harald
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Alternativer Titel
Trapidil reduces neointima formation
Abstract / Bemerkung
Smooth muscle cell (SMC) proliferation can result in luminal reduction of a vessel following balloon angioplasty. This study was designed (i) to determine if local administration of trapidil (triazolopyrimidine) into a vessel wall reduces neointima formation, and (ii) to explore the mechanism involved in the subsequent reduction in cell proliferation.
Following balloon angioplasty in 40 anaesthetized New Zealand White rabbits, trapidil (50–200 mg) or its vehicle (saline) was injected into the dilated vessel wall of the right femoral artery. Experimental groups and time of investigation: (I) vehicle (2 weeks, n=3), (II) trapidil-100 mg (2 weeks, n=3), (III) vehicle (3 weeks, n=8), (IV) trapidil-50 mg (3 weeks, n=5); (V) trapidil-100 mg (3 weeks, n=9) or (V) trapidil-200 mg (3 weeks, n=7).
After 2 weeks, there was a significant reduction of intimal hyperplasia (expressed as intima to media area ratio) in the trapidil group compared with vehicle (0.44±0.04 vs 0.93±0.04, *P<0.05) and also a significant reduction in cell proliferation (% ratio of BrdU-positive cells to total cell number: vehicle 14±2% vs trapidil 6±1%, *P<0.05).
After 3 weeks, there was a dose-dependent reduction of intimal hyperplasia in the trapidil groups compared with vehicle (trapidil 50 mg 1.14±0.04; trapidil 100 mg 0.91±0.09*; trapidil 200 mg 0.77±0.09* vs vehicle 1.67±0.23, *P<0.05).
Thus, the local administration of trapidil to the rabbit femoral artery reduces the neointima formation, which occurs 2 or 3 weeks after balloon angioplasty via a mechanism, which is dependent on inhibition of cell proliferation.
Erscheinungsjahr
2000
Zeitschriftentitel
British Journal of Pharmacology
Band
129
Ausgabe
3
Seite(n)
566-572
ISSN
00071188
Page URI
https://pub.uni-bielefeld.de/record/2965354
Zitieren
Zacharowski K, Schneidmüller D, Ibe W, et al. Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model. British Journal of Pharmacology. 2000;129(3):566-572.
Zacharowski, K., Schneidmüller, D., Ibe, W., Grosser, T., Buerke, M., Meyer, J., & Darius, H. (2000). Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model. British Journal of Pharmacology, 129(3), 566-572. https://doi.org/10.1038/sj.bjp.0703098
Zacharowski, Kai, Schneidmüller, Dorien, Ibe, Waltraut, Grosser, Tilo, Buerke, Michael, Meyer, Jürgen, and Darius, Harald. 2000. “Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model”. British Journal of Pharmacology 129 (3): 566-572.
Zacharowski, K., Schneidmüller, D., Ibe, W., Grosser, T., Buerke, M., Meyer, J., and Darius, H. (2000). Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model. British Journal of Pharmacology 129, 566-572.
Zacharowski, K., et al., 2000. Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model. British Journal of Pharmacology, 129(3), p 566-572.
K. Zacharowski, et al., “Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model”, British Journal of Pharmacology, vol. 129, 2000, pp. 566-572.
Zacharowski, K., Schneidmüller, D., Ibe, W., Grosser, T., Buerke, M., Meyer, J., Darius, H.: Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model. British Journal of Pharmacology. 129, 566-572 (2000).
Zacharowski, Kai, Schneidmüller, Dorien, Ibe, Waltraut, Grosser, Tilo, Buerke, Michael, Meyer, Jürgen, and Darius, Harald. “Effects of local delivery of trapidil on neointima formation in a rabbit angioplasty model”. British Journal of Pharmacology 129.3 (2000): 566-572.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
References
Daten bereitgestellt von Europe PubMed Central.
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 10711356
PubMed | Europe PMC
Suchen in