Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta

Rudic RD, McNamara P, Reilly D, Grosser T, Curtis A-M, Price TS, Panda S, Hogenesch JB, FitzGerald GA (2005)
Circulation 112(17): 2716-2724.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Rudic, R. Daniel; McNamara, Peter; Reilly, Dermot; Grosser, TiloUniBi ; Curtis, Anne-Marie; Price, Thomas S.; Panda, Satchidananda; Hogenesch, John B.; FitzGerald, Garret A.
Abstract / Bemerkung
Background—Circadian rhythmicity of many aspects of cardiovascular function—blood pressure, coagulation and contractile function—is well established, as is diurnal variation in important clinical events, such as myocardial infarction and stroke. Here, we undertake studies to globally assess circadian gene expression in murine aorta.Methods and Results—Aortae from mice were harvested at 4-hour intervals for 2 circadian cycles (48 hours). Gene expression was assessed by expression profiling and subjected to a gene ontology bioinformatics analysis. Three hundred thirty transcripts exhibited a circadian pattern of oscillation in mouse aorta, including those intrinsic to the function of the molecular clock. In addition, many genes relevant to protein folding, protein degradation, glucose and lipid metabolism, adipocyte maturation, vascular integrity, and the response to injury are also included in this subset of roughly 7000 genes screened for circadian oscillation.Conclusions—Detection of functional cassettes of vascular genes that exhibit circadian regulation in the mouse will facilitate elucidation of the mechanisms by which the molecular clock may interact with environmental variables to modulate cardiovascular function and the response to therapeutic interventions.
Erscheinungsjahr
2005
Zeitschriftentitel
Circulation
Band
112
Ausgabe
17
Seite(n)
2716-2724
ISSN
0009-7322
eISSN
1524-4539
Page URI
https://pub.uni-bielefeld.de/record/2965348

Zitieren

Rudic RD, McNamara P, Reilly D, et al. Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta. Circulation. 2005;112(17):2716-2724.
Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A. - M., Price, T. S., Panda, S., et al. (2005). Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta. Circulation, 112(17), 2716-2724. https://doi.org/10.1161/CIRCULATIONAHA.105.568626
Rudic, R. Daniel, McNamara, Peter, Reilly, Dermot, Grosser, Tilo, Curtis, Anne-Marie, Price, Thomas S., Panda, Satchidananda, Hogenesch, John B., and FitzGerald, Garret A. 2005. “Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta”. Circulation 112 (17): 2716-2724.
Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A. - M., Price, T. S., Panda, S., Hogenesch, J. B., and FitzGerald, G. A. (2005). Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta. Circulation 112, 2716-2724.
Rudic, R.D., et al., 2005. Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta. Circulation, 112(17), p 2716-2724.
R.D. Rudic, et al., “Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta”, Circulation, vol. 112, 2005, pp. 2716-2724.
Rudic, R.D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.-M., Price, T.S., Panda, S., Hogenesch, J.B., FitzGerald, G.A.: Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta. Circulation. 112, 2716-2724 (2005).
Rudic, R. Daniel, McNamara, Peter, Reilly, Dermot, Grosser, Tilo, Curtis, Anne-Marie, Price, Thomas S., Panda, Satchidananda, Hogenesch, John B., and FitzGerald, Garret A. “Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta”. Circulation 112.17 (2005): 2716-2724.
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 16230482
PubMed | Europe PMC

Suchen in

Google Scholar