Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy
Price TS, Grosser T, Plomin R, Jaffee SR (2010)
Child Development 81(1): 101-114.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Price, Thomas S.;
Grosser, TiloUniBi
;
Plomin, Robert;
Jaffee, Sara R.
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Abstract / Bemerkung
Maternal smoking during pregnancy retards fetal growth and depresses infant birth weight. The magnitude of these effects may be moderated by fetal genotype. The current study investigated maternal smoking, fetal genotype, and fetal growth in a large population sample of dizygotic twins. Maternal smoking retarded fetal growth in a dose-dependent fashion. In a subsample of 497 twin pairs whose mothers smoked during pregnancy, a functional polymorphism in the NAD(P)H:quinone oxidoreductase gene (NQO1 Pro187Ser; rs1800566) was significantly associated with fetal growth within families. The effect was strongest among moderate smokers. This is the first demonstration that fetal genotype for an enzyme involved in tobacco smoke metabolism influences intrauterine growth independent of maternal genotype. Future studies should conduct formal tests of Fetal Genotype × Maternal Smoking interactions.
Erscheinungsjahr
2010
Zeitschriftentitel
Child Development
Band
81
Ausgabe
1
Seite(n)
101-114
ISSN
00093920
eISSN
14678624
Page URI
https://pub.uni-bielefeld.de/record/2965331
Zitieren
Price TS, Grosser T, Plomin R, Jaffee SR. Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy. Child Development. 2010;81(1):101-114.
Price, T. S., Grosser, T., Plomin, R., & Jaffee, S. R. (2010). Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy. Child Development, 81(1), 101-114. https://doi.org/10.1111/j.1467-8624.2009.01383.x
Price, Thomas S., Grosser, Tilo, Plomin, Robert, and Jaffee, Sara R. 2010. “Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy”. Child Development 81 (1): 101-114.
Price, T. S., Grosser, T., Plomin, R., and Jaffee, S. R. (2010). Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy. Child Development 81, 101-114.
Price, T.S., et al., 2010. Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy. Child Development, 81(1), p 101-114.
T.S. Price, et al., “Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy”, Child Development, vol. 81, 2010, pp. 101-114.
Price, T.S., Grosser, T., Plomin, R., Jaffee, S.R.: Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy. Child Development. 81, 101-114 (2010).
Price, Thomas S., Grosser, Tilo, Plomin, Robert, and Jaffee, Sara R. “Fetal Genotype for the Xenobiotic Metabolizing Enzyme Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy”. Child Development 81.1 (2010): 101-114.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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Daten bereitgestellt von Europe PubMed Central.
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Daten bereitgestellt von Europe PubMed Central.
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