Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga
Grosser T, Yu Y, FitzGerald GA (2010)
Annual Review of Medicine 61(1): 17-33.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Grosser, TiloUniBi
;
Yu, Ying;
FitzGerald, Garret A.
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Abstract / Bemerkung
Nonsteroidal antinflammatory drugs (NSAIDs) inhibit prostaglandin formation by cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely than traditional drugs to cause serious gastrointestinal adverse effects, but predispose to adverse cardiovascular events, such as heart failure, myocardial infarction, and stroke. Evidence from human pharmacology and genetics, genetically manipulated rodents, and other animal models and randomized trials indicates that this is consequent to suppression of COX-2-dependent cardioprotective prostagladins, particularly prostacyclin. Lessons drawn from how this saga unfolded are relevant to how we approach drug surveillance and regulation, integrate diversifed forms of information and might pursue a more personalized approach to drug efficacy and risk.
Erscheinungsjahr
2010
Zeitschriftentitel
Annual Review of Medicine
Band
61
Ausgabe
1
Seite(n)
17-33
ISSN
0066-4219
eISSN
1545-326X
Page URI
https://pub.uni-bielefeld.de/record/2965330
Zitieren
Grosser T, Yu Y, FitzGerald GA. Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga. Annual Review of Medicine. 2010;61(1):17-33.
Grosser, T., Yu, Y., & FitzGerald, G. A. (2010). Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga. Annual Review of Medicine, 61(1), 17-33. https://doi.org/10.1146/annurev-med-011209-153129
Grosser, Tilo, Yu, Ying, and FitzGerald, Garret A. 2010. “Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga”. Annual Review of Medicine 61 (1): 17-33.
Grosser, T., Yu, Y., and FitzGerald, G. A. (2010). Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga. Annual Review of Medicine 61, 17-33.
Grosser, T., Yu, Y., & FitzGerald, G.A., 2010. Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga. Annual Review of Medicine, 61(1), p 17-33.
T. Grosser, Y. Yu, and G.A. FitzGerald, “Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga”, Annual Review of Medicine, vol. 61, 2010, pp. 17-33.
Grosser, T., Yu, Y., FitzGerald, G.A.: Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga. Annual Review of Medicine. 61, 17-33 (2010).
Grosser, Tilo, Yu, Ying, and FitzGerald, Garret A. “Emotion Recollected in Tranquility: Lessons Learned from the COX-2 Saga”. Annual Review of Medicine 61.1 (2010): 17-33.
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