Understanding multicellular function and disease with human tissue-specific networks
Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, et al. (2015)
Nature Genetics 47(6): 569-576.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Greene, Casey S;
Krishnan, Arjun;
Wong, Aaron K;
Ricciotti, Emanuela;
Zelaya, Rene A;
Himmelstein, Daniel S;
Zhang, Ran;
Hartmann, Boris M;
Zaslavsky, Elena;
Sealfon, Stuart C;
Chasman, Daniel I;
FitzGerald, Garret A
Alle
Alle
Abstract / Bemerkung
Tissue and cell-type identity lie at the core of human physiology and disease. Understanding the genetic underpinnings of complex tissues and individual cell lineages is crucial for developing improved diagnostics and therapeutics. We present genome-wide functional interaction networks for 144 human tissues and cell types developed using a data-driven Bayesian methodology that integrates thousands of diverse experiments spanning tissue and disease states. Tissue-specific networks predict lineage-specific responses to perturbation, identify the changing functional roles of genes across tissues and illuminate relationships among diseases. We introduce NetWAS, which combines genes with nominally significant genome-wide association study (GWAS) P values and tissue-specific networks to identify disease-gene associations more accurately than GWAS alone. Our webserver, GIANT, provides an interface to human tissue networks through multi-gene queries, network visualization, analysis tools including NetWAS and downloadable networks. GIANT enables systematic exploration of the landscape of interacting genes that shape specialized cellular functions across more than a hundred human tissues and cell types.
Erscheinungsjahr
2015
Zeitschriftentitel
Nature Genetics
Band
47
Ausgabe
6
Seite(n)
569-576
ISSN
1061-4036
eISSN
1546-1718
Page URI
https://pub.uni-bielefeld.de/record/2965316
Zitieren
Greene CS, Krishnan A, Wong AK, et al. Understanding multicellular function and disease with human tissue-specific networks. Nature Genetics. 2015;47(6):569-576.
Greene, C. S., Krishnan, A., Wong, A. K., Ricciotti, E., Zelaya, R. A., Himmelstein, D. S., Zhang, R., et al. (2015). Understanding multicellular function and disease with human tissue-specific networks. Nature Genetics, 47(6), 569-576. https://doi.org/10.1038/ng.3259
Greene, Casey S, Krishnan, Arjun, Wong, Aaron K, Ricciotti, Emanuela, Zelaya, Rene A, Himmelstein, Daniel S, Zhang, Ran, et al. 2015. “Understanding multicellular function and disease with human tissue-specific networks”. Nature Genetics 47 (6): 569-576.
Greene, C. S., Krishnan, A., Wong, A. K., Ricciotti, E., Zelaya, R. A., Himmelstein, D. S., Zhang, R., Hartmann, B. M., Zaslavsky, E., Sealfon, S. C., et al. (2015). Understanding multicellular function and disease with human tissue-specific networks. Nature Genetics 47, 569-576.
Greene, C.S., et al., 2015. Understanding multicellular function and disease with human tissue-specific networks. Nature Genetics, 47(6), p 569-576.
C.S. Greene, et al., “Understanding multicellular function and disease with human tissue-specific networks”, Nature Genetics, vol. 47, 2015, pp. 569-576.
Greene, C.S., Krishnan, A., Wong, A.K., Ricciotti, E., Zelaya, R.A., Himmelstein, D.S., Zhang, R., Hartmann, B.M., Zaslavsky, E., Sealfon, S.C., Chasman, D.I., FitzGerald, G.A., Dolinski, K., Grosser, T., Troyanskaya, O.G.: Understanding multicellular function and disease with human tissue-specific networks. Nature Genetics. 47, 569-576 (2015).
Greene, Casey S, Krishnan, Arjun, Wong, Aaron K, Ricciotti, Emanuela, Zelaya, Rene A, Himmelstein, Daniel S, Zhang, Ran, Hartmann, Boris M, Zaslavsky, Elena, Sealfon, Stuart C, Chasman, Daniel I, FitzGerald, Garret A, Dolinski, Kara, Grosser, Tilo, and Troyanskaya, Olga G. “Understanding multicellular function and disease with human tissue-specific networks”. Nature Genetics 47.6 (2015): 569-576.
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