Timing of expression of the core clock gene influences its effects on aging and survival

Yang G, Chen L, Grant GR, Paschos G, Song W-L, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA (2016)
Science Translational Medicine 8(324).

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Yang, Guangrui; Chen, Lihong; Grant, Gregory R.; Paschos, Georgios; Song, Wen-Liang; Musiek, Erik S.; Lee, Vivian; McLoughlin, Sarah C.; Grosser, TiloUniBi ; Cotsarelis, George; FitzGerald, Garret A.
Abstract / Bemerkung
The absence of Bmal1, a core clock gene, results in a loss of circadian rhythms, an acceleration of aging, and a shortened life span in mice. To address the importance of circadian rhythms in the aging process, we generated conditional Bmal1 knockout mice that lacked the BMAL1 protein during adult life and found that wild-type circadian variations in wheel-running activity, heart rate, and blood pressure were abolished. Ocular abnormalities and brain astrogliosis were conserved irrespective of the timing of Bmal1 deletion. However, life span, fertility, body weight, blood glucose levels, and age-dependent arthropathy, which are altered in standard Bmal1 knockout mice, remained unaltered, whereas atherosclerosis and hair growth improved, in the conditional adult-life Bmal1 knockout mice, despite abolition of clock function. Hepatic RNA-Seq revealed that expression of oscillatory genes was dampened in the adult-life Bmal1 knockout mice, whereas overall gene expression was largely unchanged. Thus, many phenotypes in conventional Bmal1 knockout mice, hitherto attributed to disruption of circadian rhythms, reflect the loss of properties of BMAL1 that are independent of its role in the clock. These findings prompt reevaluation of the systemic consequences of disruption of the molecular clock.
Erscheinungsjahr
2016
Zeitschriftentitel
Science Translational Medicine
Band
8
Ausgabe
324
ISSN
1946-6234
eISSN
1946-6242
Page URI
https://pub.uni-bielefeld.de/record/2965315

Zitieren

Yang G, Chen L, Grant GR, et al. Timing of expression of the core clock gene influences its effects on aging and survival. Science Translational Medicine. 2016;8(324).
Yang, G., Chen, L., Grant, G. R., Paschos, G., Song, W. - L., Musiek, E. S., Lee, V., et al. (2016). Timing of expression of the core clock gene influences its effects on aging and survival. Science Translational Medicine, 8(324). https://doi.org/10.1126/scitranslmed.aad3305
Yang, Guangrui, Chen, Lihong, Grant, Gregory R., Paschos, Georgios, Song, Wen-Liang, Musiek, Erik S., Lee, Vivian, et al. 2016. “Timing of expression of the core clock gene influences its effects on aging and survival”. Science Translational Medicine 8 (324).
Yang, G., Chen, L., Grant, G. R., Paschos, G., Song, W. - L., Musiek, E. S., Lee, V., McLoughlin, S. C., Grosser, T., Cotsarelis, G., et al. (2016). Timing of expression of the core clock gene influences its effects on aging and survival. Science Translational Medicine 8.
Yang, G., et al., 2016. Timing of expression of the core clock gene influences its effects on aging and survival. Science Translational Medicine, 8(324).
G. Yang, et al., “Timing of expression of the core clock gene influences its effects on aging and survival”, Science Translational Medicine, vol. 8, 2016.
Yang, G., Chen, L., Grant, G.R., Paschos, G., Song, W.-L., Musiek, E.S., Lee, V., McLoughlin, S.C., Grosser, T., Cotsarelis, G., FitzGerald, G.A.: Timing of expression of the core clock gene influences its effects on aging and survival. Science Translational Medicine. 8, (2016).
Yang, Guangrui, Chen, Lihong, Grant, Gregory R., Paschos, Georgios, Song, Wen-Liang, Musiek, Erik S., Lee, Vivian, McLoughlin, Sarah C., Grosser, Tilo, Cotsarelis, George, and FitzGerald, Garret A. “Timing of expression of the core clock gene influences its effects on aging and survival”. Science Translational Medicine 8.324 (2016).

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