Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain
Theken KN, Hersh EV, Lahens NF, Lee HM, Li X, Granquist EJ, Giannakopoulos HE, Levin LM, Secreto SA, Grant GR, Detre JA, et al. (2019)
Clinical Pharmacology & Therapeutics 106(3): 632-641.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Theken, Katherine N.;
Hersh, Elliot V.;
Lahens, Nicholas F.;
Lee, Hyo Min;
Li, Xuanwen;
Granquist, Eric J.;
Giannakopoulos, Helen E.;
Levin, Lawrence M.;
Secreto, Stacey A.;
Grant, Gregory R.;
Detre, John A.;
FitzGerald, Garret A.
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Abstract / Bemerkung
The mechanisms underlying interindividual variability in analgesic efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) are not well understood. Therefore, we performed pain phenotyping, functional neuroimaging, pharmacokinetic/pharmacodynamic assessments, inflammation biomarkers, and gene expression profiling in healthy subjects who underwent surgical extraction of bony impacted third molars and were treated with ibuprofen (400 mg; N = 19) or placebo (N = 10). Analgesic efficacy was not associated with demographic or clinical characteristics, ibuprofen pharmacokinetics, or the degree of cyclooxygenase inhibition by ibuprofen. Compared with partial responders to ibuprofen (N = 9, required rescue medication within the dosing interval), complete responders (N = 10, no rescue medication) exhibited greater induction of urinary prostaglandin metabolites and serum tumor necrosis factor-α and interleukin 8. Differentially expressed genes in peripheral blood mononuclear cells were enriched for inflammation-related pathways. These findings suggest that a less pronounced activation of the inflammatory prostanoid system is associated with insufficient pain relief on ibuprofen alone and the need for additional therapeutic intervention.
Erscheinungsjahr
2019
Zeitschriftentitel
Clinical Pharmacology & Therapeutics
Band
106
Ausgabe
3
Seite(n)
632-641
Urheberrecht / Lizenzen
ISSN
0009-9236
eISSN
1532-6535
Page URI
https://pub.uni-bielefeld.de/record/2965304
Zitieren
Theken KN, Hersh EV, Lahens NF, et al. Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain. Clinical Pharmacology & Therapeutics. 2019;106(3):632-641.
Theken, K. N., Hersh, E. V., Lahens, N. F., Lee, H. M., Li, X., Granquist, E. J., Giannakopoulos, H. E., et al. (2019). Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain. Clinical Pharmacology & Therapeutics, 106(3), 632-641. https://doi.org/10.1002/cpt.1446
Theken, Katherine N., Hersh, Elliot V., Lahens, Nicholas F., Lee, Hyo Min, Li, Xuanwen, Granquist, Eric J., Giannakopoulos, Helen E., et al. 2019. “Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain”. Clinical Pharmacology & Therapeutics 106 (3): 632-641.
Theken, K. N., Hersh, E. V., Lahens, N. F., Lee, H. M., Li, X., Granquist, E. J., Giannakopoulos, H. E., Levin, L. M., Secreto, S. A., Grant, G. R., et al. (2019). Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain. Clinical Pharmacology & Therapeutics 106, 632-641.
Theken, K.N., et al., 2019. Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain. Clinical Pharmacology & Therapeutics, 106(3), p 632-641.
K.N. Theken, et al., “Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain”, Clinical Pharmacology & Therapeutics, vol. 106, 2019, pp. 632-641.
Theken, K.N., Hersh, E.V., Lahens, N.F., Lee, H.M., Li, X., Granquist, E.J., Giannakopoulos, H.E., Levin, L.M., Secreto, S.A., Grant, G.R., Detre, J.A., FitzGerald, G.A., Grosser, T., Farrar, J.T.: Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain. Clinical Pharmacology & Therapeutics. 106, 632-641 (2019).
Theken, Katherine N., Hersh, Elliot V., Lahens, Nicholas F., Lee, Hyo Min, Li, Xuanwen, Granquist, Eric J., Giannakopoulos, Helen E., Levin, Lawrence M., Secreto, Stacey A., Grant, Gregory R., Detre, John A., FitzGerald, Garret A., Grosser, Tilo, and Farrar, John T. “Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain”. Clinical Pharmacology & Therapeutics 106.3 (2019): 632-641.
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