Nitecap: An Exploratory Circadian Analysis Web Application
Brooks TG, Mrčela A, Lahens NF, Paschos GK, Grosser T, Skarke C, FitzGerald GA, Grant GR (2022)
Journal of Biological Rhythms 37(1): 43-52.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Brooks, Thomas G.;
Mrčela, Antonijo;
Lahens, Nicholas F.;
Paschos, Georgios K.;
Grosser, TiloUniBi
;
Skarke, Carsten;
FitzGerald, Garret A.;
Grant, Gregory R.
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Abstract / Bemerkung
Circadian omics analyses present investigators with large amounts of data to consider and many choices for methods of analysis. Visualization is crucial as rhythmicity can take many forms and p-values offer an incomplete picture. Yet statically viewing the entirety of high-throughput datasets is impractical, and there is often limited ability to assess the impact of choices, such as significance threshold cutoffs. Nitecap provides an intuitive and unified web-based solution to these problems. Through highly responsive visualizations, Nitecap enables investigators to see dataset-wide behavior. It supports deep analyses, including comparisons of two conditions. Moreover, it focuses upon ease-of-use and enables collaboration through dataset sharing. As an application, we investigated cross talk between peripheral clocks in adipose and liver tissues and determined that adipocyte clock disruption does not substantially modulate the transcriptional rhythmicity of liver but does advance the phase of core clock gene Bmal1 (Arntl) expression in the liver. Nitecap is available at nitecap.org and is free-to-use.
Erscheinungsjahr
2022
Zeitschriftentitel
Journal of Biological Rhythms
Band
37
Ausgabe
1
Seite(n)
43-52
Urheberrecht / Lizenzen
ISSN
0748-7304
eISSN
1552-4531
Page URI
https://pub.uni-bielefeld.de/record/2965300
Zitieren
Brooks TG, Mrčela A, Lahens NF, et al. Nitecap: An Exploratory Circadian Analysis Web Application. Journal of Biological Rhythms. 2022;37(1):43-52.
Brooks, T. G., Mrčela, A., Lahens, N. F., Paschos, G. K., Grosser, T., Skarke, C., FitzGerald, G. A., et al. (2022). Nitecap: An Exploratory Circadian Analysis Web Application. Journal of Biological Rhythms, 37(1), 43-52. https://doi.org/10.1177/07487304211054408
Brooks, Thomas G., Mrčela, Antonijo, Lahens, Nicholas F., Paschos, Georgios K., Grosser, Tilo, Skarke, Carsten, FitzGerald, Garret A., and Grant, Gregory R. 2022. “Nitecap: An Exploratory Circadian Analysis Web Application”. Journal of Biological Rhythms 37 (1): 43-52.
Brooks, T. G., Mrčela, A., Lahens, N. F., Paschos, G. K., Grosser, T., Skarke, C., FitzGerald, G. A., and Grant, G. R. (2022). Nitecap: An Exploratory Circadian Analysis Web Application. Journal of Biological Rhythms 37, 43-52.
Brooks, T.G., et al., 2022. Nitecap: An Exploratory Circadian Analysis Web Application. Journal of Biological Rhythms, 37(1), p 43-52.
T.G. Brooks, et al., “Nitecap: An Exploratory Circadian Analysis Web Application”, Journal of Biological Rhythms, vol. 37, 2022, pp. 43-52.
Brooks, T.G., Mrčela, A., Lahens, N.F., Paschos, G.K., Grosser, T., Skarke, C., FitzGerald, G.A., Grant, G.R.: Nitecap: An Exploratory Circadian Analysis Web Application. Journal of Biological Rhythms. 37, 43-52 (2022).
Brooks, Thomas G., Mrčela, Antonijo, Lahens, Nicholas F., Paschos, Georgios K., Grosser, Tilo, Skarke, Carsten, FitzGerald, Garret A., and Grant, Gregory R. “Nitecap: An Exploratory Circadian Analysis Web Application”. Journal of Biological Rhythms 37.1 (2022): 43-52.
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