Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation

Myerson, Jacob W.; Patel, Priyal N.; Rubey, Kathryn M.; Zamora, Marco E.; Zaleski, Michael H.; Habibi, Nahal; Walsh, Landis R.; Lee, Yi-Wei; Luther, David C.; Ferguson, Laura T.; Marcos-Contreras, Oscar A.; Glassman, Patrick M.; Mazaleuskaya, Liudmila L.; Johnston, Ian; Hood, Elizabeth D.; Shuvaeva, Tea; Wu, Jichuan; Zhang, Hong-Ying; Gregory, Jason V.; Kiseleva, Raisa Y.; Nong, Jia; Grosser, Tilo; Greineder, Colin F.; Mitragotri, Samir; Worthen, George S.; Rotello, Vincent M.; Lahann, Joerg; Muzykantov, Vladimir R.; Brenner, Jacob S.

Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation

Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee Y-W, Luther DC, Ferguson LT, Marcos-Contreras OA, et al. (2022)
Nature Nanotechnology 17(1): 86-97.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1038/s41565-021-00997-y

Autor*in

Myerson, Jacob W.; Patel, Priyal N.; Rubey, Kathryn M.; Zamora, Marco E.; Zaleski, Michael H.; Habibi, Nahal; Walsh, Landis R.; Lee, Yi-Wei; Luther, David C.; Ferguson, Laura T.; Marcos-Contreras, Oscar A.; Glassman, Patrick M.
Alle

Einrichtung

Medizinische Fakultät OWL > AG 13 Translationale Pharmakologie

Abstract / Bemerkung

This study shows that the supramolecular arrangement of proteins in nanoparticle structures predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We observed homing to inflamed lungs for a variety of nanoparticles with agglutinated protein (NAPs), defined by arrangement of protein in or on the nanoparticles via hydrophobic interactions, crosslinking and electrostatic interactions. Nanoparticles with symmetric protein arrangement (for example, viral capsids) had no selectivity for inflamed lungs. Flow cytometry and immunohistochemistry showed NAPs have tropism for pulmonary neutrophils. Protein-conjugated liposomes were engineered to recapitulate NAP tropism for pulmonary neutrophils. NAP uptake in neutrophils was shown to depend on complement opsonization. We demonstrate diagnostic imaging of ALI with NAPs; show NAP tropism for inflamed human donor lungs; and show that NAPs can remediate pulmonary oedema in ALI. This work demonstrates that structure-dependent tropism for neutrophils drives NAPs to inflamed lungs and shows NAPs can detect and treat ALI.

Erscheinungsjahr

2022

Zeitschriftentitel

Nature Nanotechnology

Band

Ausgabe

Seite(n)

86-97

ISSN

1748-3387

eISSN

1748-3395

Page URI

https://pub.uni-bielefeld.de/record/2965299

Zitieren

Myerson JW, Patel PN, Rubey KM, et al. Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology. 2022;17(1):86-97.

Myerson, J. W., Patel, P. N., Rubey, K. M., Zamora, M. E., Zaleski, M. H., Habibi, N., Walsh, L. R., et al. (2022). Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology, 17(1), 86-97. https://doi.org/10.1038/s41565-021-00997-y

Myerson, Jacob W., Patel, Priyal N., Rubey, Kathryn M., Zamora, Marco E., Zaleski, Michael H., Habibi, Nahal, Walsh, Landis R., et al. 2022. “Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation”. Nature Nanotechnology 17 (1): 86-97.

Myerson, J. W., Patel, P. N., Rubey, K. M., Zamora, M. E., Zaleski, M. H., Habibi, N., Walsh, L. R., Lee, Y. - W., Luther, D. C., Ferguson, L. T., et al. (2022). Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology 17, 86-97.

Myerson, J.W., et al., 2022. Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology, 17(1), p 86-97.

J.W. Myerson, et al., “Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation”, Nature Nanotechnology, vol. 17, 2022, pp. 86-97.

Myerson, J.W., Patel, P.N., Rubey, K.M., Zamora, M.E., Zaleski, M.H., Habibi, N., Walsh, L.R., Lee, Y.-W., Luther, D.C., Ferguson, L.T., Marcos-Contreras, O.A., Glassman, P.M., Mazaleuskaya, L.L., Johnston, I., Hood, E.D., Shuvaeva, T., Wu, J., Zhang, H.-Y., Gregory, J.V., Kiseleva, R.Y., Nong, J., Grosser, T., Greineder, C.F., Mitragotri, S., Worthen, G.S., Rotello, V.M., Lahann, J., Muzykantov, V.R., Brenner, J.S.: Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology. 17, 86-97 (2022).

Myerson, Jacob W., Patel, Priyal N., Rubey, Kathryn M., Zamora, Marco E., Zaleski, Michael H., Habibi, Nahal, Walsh, Landis R., Lee, Yi-Wei, Luther, David C., Ferguson, Laura T., Marcos-Contreras, Oscar A., Glassman, Patrick M., Mazaleuskaya, Liudmila L., Johnston, Ian, Hood, Elizabeth D., Shuvaeva, Tea, Wu, Jichuan, Zhang, Hong-Ying, Gregory, Jason V., Kiseleva, Raisa Y., Nong, Jia, Grosser, Tilo, Greineder, Colin F., Mitragotri, Samir, Worthen, George S., Rotello, Vincent M., Lahann, Joerg, Muzykantov, Vladimir R., and Brenner, Jacob S. “Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation”. Nature Nanotechnology 17.1 (2022): 86-97.

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