Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation
Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee Y-W, Luther DC, Ferguson LT, Marcos-Contreras OA, et al. (2022)
Nature Nanotechnology 17(1): 86-97.
Zeitschriftenaufsatz
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Autor*in
Myerson, Jacob W.;
Patel, Priyal N.;
Rubey, Kathryn M.;
Zamora, Marco E.;
Zaleski, Michael H.;
Habibi, Nahal;
Walsh, Landis R.;
Lee, Yi-Wei;
Luther, David C.;
Ferguson, Laura T.;
Marcos-Contreras, Oscar A.;
Glassman, Patrick M.
Alle
Alle
Abstract / Bemerkung
This study shows that the supramolecular arrangement of proteins in nanoparticle structures predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We observed homing to inflamed lungs for a variety of nanoparticles with agglutinated protein (NAPs), defined by arrangement of protein in or on the nanoparticles via hydrophobic interactions, crosslinking and electrostatic interactions. Nanoparticles with symmetric protein arrangement (for example, viral capsids) had no selectivity for inflamed lungs. Flow cytometry and immunohistochemistry showed NAPs have tropism for pulmonary neutrophils. Protein-conjugated liposomes were engineered to recapitulate NAP tropism for pulmonary neutrophils. NAP uptake in neutrophils was shown to depend on complement opsonization. We demonstrate diagnostic imaging of ALI with NAPs; show NAP tropism for inflamed human donor lungs; and show that NAPs can remediate pulmonary oedema in ALI. This work demonstrates that structure-dependent tropism for neutrophils drives NAPs to inflamed lungs and shows NAPs can detect and treat ALI.
Erscheinungsjahr
2022
Zeitschriftentitel
Nature Nanotechnology
Band
17
Ausgabe
1
Seite(n)
86-97
ISSN
1748-3387
eISSN
1748-3395
Page URI
https://pub.uni-bielefeld.de/record/2965299
Zitieren
Myerson JW, Patel PN, Rubey KM, et al. Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology. 2022;17(1):86-97.
Myerson, J. W., Patel, P. N., Rubey, K. M., Zamora, M. E., Zaleski, M. H., Habibi, N., Walsh, L. R., et al. (2022). Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology, 17(1), 86-97. https://doi.org/10.1038/s41565-021-00997-y
Myerson, Jacob W., Patel, Priyal N., Rubey, Kathryn M., Zamora, Marco E., Zaleski, Michael H., Habibi, Nahal, Walsh, Landis R., et al. 2022. “Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation”. Nature Nanotechnology 17 (1): 86-97.
Myerson, J. W., Patel, P. N., Rubey, K. M., Zamora, M. E., Zaleski, M. H., Habibi, N., Walsh, L. R., Lee, Y. - W., Luther, D. C., Ferguson, L. T., et al. (2022). Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology 17, 86-97.
Myerson, J.W., et al., 2022. Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology, 17(1), p 86-97.
J.W. Myerson, et al., “Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation”, Nature Nanotechnology, vol. 17, 2022, pp. 86-97.
Myerson, J.W., Patel, P.N., Rubey, K.M., Zamora, M.E., Zaleski, M.H., Habibi, N., Walsh, L.R., Lee, Y.-W., Luther, D.C., Ferguson, L.T., Marcos-Contreras, O.A., Glassman, P.M., Mazaleuskaya, L.L., Johnston, I., Hood, E.D., Shuvaeva, T., Wu, J., Zhang, H.-Y., Gregory, J.V., Kiseleva, R.Y., Nong, J., Grosser, T., Greineder, C.F., Mitragotri, S., Worthen, G.S., Rotello, V.M., Lahann, J., Muzykantov, V.R., Brenner, J.S.: Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology. 17, 86-97 (2022).
Myerson, Jacob W., Patel, Priyal N., Rubey, Kathryn M., Zamora, Marco E., Zaleski, Michael H., Habibi, Nahal, Walsh, Landis R., Lee, Yi-Wei, Luther, David C., Ferguson, Laura T., Marcos-Contreras, Oscar A., Glassman, Patrick M., Mazaleuskaya, Liudmila L., Johnston, Ian, Hood, Elizabeth D., Shuvaeva, Tea, Wu, Jichuan, Zhang, Hong-Ying, Gregory, Jason V., Kiseleva, Raisa Y., Nong, Jia, Grosser, Tilo, Greineder, Colin F., Mitragotri, Samir, Worthen, George S., Rotello, Vincent M., Lahann, Joerg, Muzykantov, Vladimir R., and Brenner, Jacob S. “Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation”. Nature Nanotechnology 17.1 (2022): 86-97.
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