Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation
Kim J, Hong G, Mazaleuskaya L, Hsu JC, Rosario-Berrios DN, Grosser T, Cho-Park PF, Cormode DP (2021)
ACS Applied Materials & Interfaces 13(51): 60852-60864.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Kim, Johoon;
Hong, Gwanui;
Mazaleuskaya, Luda;
Hsu, Jessica C.;
Rosario-Berrios, Derick N.;
Grosser, TiloUniBi
;
Cho-Park, Park F.;
Cormode, David P.
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Abstract / Bemerkung
Cerium oxide nanoparticles (CeONP), having potent antioxidant properties, are highly promising nanomaterials for treatment of diseases in which oxidative stress from excessive reactive oxygen species (ROS) plays a critical role in the pathogenesis and progression. However, most previously reported CeONP formulations were not efficiently cleared from the body, precluding their clinical translation. Herein, we report ultrasmall CeONP that can mitigate activation of macrophages and subsequent acute inflammation. It is found that these CeONP can effectively scavenge reactive species, inhibit macrophage activation, and minimize their recruitment and infiltration to the inflammation site, which lead to alleviation of edema and pain hypersensitivity. Moreover, we demonstrate that CeONP can be effectively excreted from the body within 24 h of systemic administration, minimizing long-term toxicity concerns. Altogether, our findings suggest that CeONP may be explored as both antioxidant and anti-inflammatory agents that can reduce acute inflammation with a better safety profile than existing nanoparticles.
Stichworte
nanoparticle;
macrophage;
inflammation;
cerium oxide;
nanozyme
Erscheinungsjahr
2021
Zeitschriftentitel
ACS Applied Materials & Interfaces
Band
13
Ausgabe
51
Seite(n)
60852-60864
ISSN
1944-8244
eISSN
1944-8252
Page URI
https://pub.uni-bielefeld.de/record/2965297
Zitieren
Kim J, Hong G, Mazaleuskaya L, et al. Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation. ACS Applied Materials & Interfaces. 2021;13(51):60852-60864.
Kim, J., Hong, G., Mazaleuskaya, L., Hsu, J. C., Rosario-Berrios, D. N., Grosser, T., Cho-Park, P. F., et al. (2021). Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation. ACS Applied Materials & Interfaces, 13(51), 60852-60864. https://doi.org/10.1021/acsami.1c16126
Kim, Johoon, Hong, Gwanui, Mazaleuskaya, Luda, Hsu, Jessica C., Rosario-Berrios, Derick N., Grosser, Tilo, Cho-Park, Park F., and Cormode, David P. 2021. “Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation”. ACS Applied Materials & Interfaces 13 (51): 60852-60864.
Kim, J., Hong, G., Mazaleuskaya, L., Hsu, J. C., Rosario-Berrios, D. N., Grosser, T., Cho-Park, P. F., and Cormode, D. P. (2021). Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation. ACS Applied Materials & Interfaces 13, 60852-60864.
Kim, J., et al., 2021. Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation. ACS Applied Materials & Interfaces, 13(51), p 60852-60864.
J. Kim, et al., “Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation”, ACS Applied Materials & Interfaces, vol. 13, 2021, pp. 60852-60864.
Kim, J., Hong, G., Mazaleuskaya, L., Hsu, J.C., Rosario-Berrios, D.N., Grosser, T., Cho-Park, P.F., Cormode, D.P.: Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation. ACS Applied Materials & Interfaces. 13, 60852-60864 (2021).
Kim, Johoon, Hong, Gwanui, Mazaleuskaya, Luda, Hsu, Jessica C., Rosario-Berrios, Derick N., Grosser, Tilo, Cho-Park, Park F., and Cormode, David P. “Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation”. ACS Applied Materials & Interfaces 13.51 (2021): 60852-60864.
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