BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES

Deresa DA, Abdissa Z, Gurmessa GT, Bedane KG, Frese M, Sewald N, Abdissa Ayana N (2022)
Bulletin of the Chemical Society of Ethiopia 36(3): 667-674.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Deresa, Desalegn Abebe; Abdissa, Zelalem; Gurmessa, Getahun Tadesse; Bedane, Kibrom Gebreheiwot; Frese, MarcelUniBi ; Sewald, NorbertUniBi ; Abdissa Ayana, NegeraUniBi
Abstract / Bemerkung
Biflavonoids are C-C or C-O-C linked flavonoid dimers with highly restricted presence in plant species. They are extensively reported to possess interesting pharmacological properties. The chromatographic fractionation and purification of CH2Cl2/MeOH (1:1) extract of the root of Rhus ruspolli led to the isolation of a new biflavonoid (1) along with four other known biflavonoids (2-5). The structure of the compounds were identified based on the analysis of NMR spectroscopic and mass spectrometric data and also in comparison with reported literature data. Compounds 2-5 were assayed for their antioxidant activity using DPPH and displayed potent in vitro antioxidant activities. The percentage radical scavenging activities were 78.32, 68.90, 93.22 and 92.00 for compounds 2-5, respectively. The highest activity was observed for compound 4 and 5 with IC50 values of 7.90 and 8.40, respectively, which are even greater than that of ascorbic acid (IC50 9.90). The high antioxidant activity of the compounds could be due to the presence of free hydroxyl groups in the flavonoids. The antioxidant activities of these compounds support the traditional uses of the plant in treatment of wound, ectoparasite and as antibacteria and indicates the potential use of these compounds as drug lead candidates.
Stichworte
Rhus ruspolii; Roots; Biflavonoids; Chalcones; Antioxidant activity
Erscheinungsjahr
2022
Zeitschriftentitel
Bulletin of the Chemical Society of Ethiopia
Band
36
Ausgabe
3
Seite(n)
667-674
ISSN
1011-3924
eISSN
1726-801X
Page URI
https://pub.uni-bielefeld.de/record/2964932

Zitieren

Deresa DA, Abdissa Z, Gurmessa GT, et al. BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES. Bulletin of the Chemical Society of Ethiopia . 2022;36(3):667-674.
Deresa, D. A., Abdissa, Z., Gurmessa, G. T., Bedane, K. G., Frese, M., Sewald, N., & Abdissa Ayana, N. (2022). BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES. Bulletin of the Chemical Society of Ethiopia , 36(3), 667-674. https://doi.org/10.4314/bcse.v36i3.15
Deresa, Desalegn Abebe, Abdissa, Zelalem, Gurmessa, Getahun Tadesse, Bedane, Kibrom Gebreheiwot, Frese, Marcel, Sewald, Norbert, and Abdissa Ayana, Negera. 2022. “BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES”. Bulletin of the Chemical Society of Ethiopia 36 (3): 667-674.
Deresa, D. A., Abdissa, Z., Gurmessa, G. T., Bedane, K. G., Frese, M., Sewald, N., and Abdissa Ayana, N. (2022). BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES. Bulletin of the Chemical Society of Ethiopia 36, 667-674.
Deresa, D.A., et al., 2022. BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES. Bulletin of the Chemical Society of Ethiopia , 36(3), p 667-674.
D.A. Deresa, et al., “BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES”, Bulletin of the Chemical Society of Ethiopia , vol. 36, 2022, pp. 667-674.
Deresa, D.A., Abdissa, Z., Gurmessa, G.T., Bedane, K.G., Frese, M., Sewald, N., Abdissa Ayana, N.: BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES. Bulletin of the Chemical Society of Ethiopia . 36, 667-674 (2022).
Deresa, Desalegn Abebe, Abdissa, Zelalem, Gurmessa, Getahun Tadesse, Bedane, Kibrom Gebreheiwot, Frese, Marcel, Sewald, Norbert, and Abdissa Ayana, Negera. “BIFLAVONOIDS FROM THE ROOTS OF RHUS RUSPOLII AND EVALUATIONS OF THEIR ANTIOXIDANT ACTIVITIES”. Bulletin of the Chemical Society of Ethiopia 36.3 (2022): 667-674.
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