Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Wiegmann A, Rinaud T, Ottensmann M, Krüger O, Springer A, Legler M, Fehr M, Strube C, Chakarov N (2022)
Veterinary Sciences 9(8): 397.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Wiegmann, Anja; Rinaud, TonyUniBi; Ottensmann, MeinolfUniBi; Krüger, OliverUniBi; Springer, Andrea; Legler, Marko; Fehr, Michael; Strube, Christina; Chakarov, NaydenUniBi
Abstract / Bemerkung
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes. Knowledge of tolerance in the use of new drugs is, therefore, important to avoid severe toxicity in species, which are both commonly admitted in veterinary clinics and are of conservation concern. Antimalarial drugs have been developed for use in human medicine, but treatment with different agents has also long been used in avian medicine, as haemosporidian infections play a major role in many avian species. This study investigates the effects of the application of atovaquone–proguanil (Malarone®, GlaxoSmithKline) in common buzzards (Buteo buteo). The potential effects of treatment on body condition, growth rate, and chemical blood parameters of nestlings were assessed. All individuals survived the treatment, and no effects on body condition, growth rate, and chemical blood parameters were observed. Our results suggest the tolerability of Malarone® in common buzzards at a single dose of on average 11 mg/kg body weight. For its safe use, we recommend further studies to determine pharmacokinetics in different avian species as well as to assess the effects of repeated treatment.
Stichworte
Malarone; drug tolerance; avian malaria; haemosporidian parasites; blood chemistry; Buteo buteo
Erscheinungsjahr
2022
Zeitschriftentitel
Veterinary Sciences
Band
9
Ausgabe
8
Art.-Nr.
397
eISSN
2306-7381
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2964902

Zitieren

Wiegmann A, Rinaud T, Ottensmann M, et al. Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings. Veterinary Sciences. 2022;9(8): 397.
Wiegmann, A., Rinaud, T., Ottensmann, M., Krüger, O., Springer, A., Legler, M., Fehr, M., et al. (2022). Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings. Veterinary Sciences, 9(8), 397. https://doi.org/10.3390/vetsci9080397
Wiegmann, Anja, Rinaud, Tony, Ottensmann, Meinolf, Krüger, Oliver, Springer, Andrea, Legler, Marko, Fehr, Michael, Strube, Christina, and Chakarov, Nayden. 2022. “Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings”. Veterinary Sciences 9 (8): 397.
Wiegmann, A., Rinaud, T., Ottensmann, M., Krüger, O., Springer, A., Legler, M., Fehr, M., Strube, C., and Chakarov, N. (2022). Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings. Veterinary Sciences 9:397.
Wiegmann, A., et al., 2022. Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings. Veterinary Sciences, 9(8): 397.
A. Wiegmann, et al., “Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings”, Veterinary Sciences, vol. 9, 2022, : 397.
Wiegmann, A., Rinaud, T., Ottensmann, M., Krüger, O., Springer, A., Legler, M., Fehr, M., Strube, C., Chakarov, N.: Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings. Veterinary Sciences. 9, : 397 (2022).
Wiegmann, Anja, Rinaud, Tony, Ottensmann, Meinolf, Krüger, Oliver, Springer, Andrea, Legler, Marko, Fehr, Michael, Strube, Christina, and Chakarov, Nayden. “Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings”. Veterinary Sciences 9.8 (2022): 397.
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2022-08-04T13:22:34Z
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