Regression of Myocardial Hypertrophy After Aortic Valve Replacement

Petrov G, Regitz-Zagrosek V, Lehmkuhl E, Krabatsch T, Dunkel A, Dandel M, Dworatzek E, Mahmoodzadeh S, Schubert C, Becher E, Hampl H, et al. (2010)
Circulation 122(11_suppl_1): S23-S28.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Petrov, George; Regitz-Zagrosek, Vera; Lehmkuhl, Elke; Krabatsch, Thomas; Dunkel, Anne; Dandel, Michael; Dworatzek, Elke; Mahmoodzadeh, Shokoufeh; Schubert, Carola; Becher, EvaUniBi ; Hampl, Hannah; Hetzer, Roland
Alle
Alternativer Titel
Faster in Women?
Abstract / Bemerkung
Background—In patients with aortic stenosis, pressure overload induces cardiac hypertrophy and fibrosis. Female sex and estrogens influence cardiac remodeling and fibrosis in animal models and in men. Sex differences and their molecular mechanisms in hypertrophy regression after aortic valve replacement have not yet been studied. Methods and Results—We prospectively obtained preoperative and early postoperative echocardiography in 92 patients, 53 women and 39 men, undergoing aortic valve replacement for isolated aortic stenosis. We analyzed in a subgroup of 10 patients matrix gene expression in left ventricular (LV) biopsies. In addition, we determined the effect of 17β-estradiol on collagen synthesis in isolated rat cardiac fibroblasts. Preoperatively, women and men had similar ejection fraction. Similar percentages of women and men had increased LV diameters (37% and 38%). Women more frequently exhibited LV hypertrophy than men (women: 86%; men: 56%; P<0.01). Postoperatively, increased LV diameters persisted in 34% of men but only in 12% of women (P<0.023). LV hypertrophy reversed more frequently in women than in men, leading to a similar prevalence of LV hypertrophy after surgery (women: 45%; men: 36%). In surgical biopsies, men had significantly higher collagen I and III and matrix metalloproteinase 2 gene expression than women. In isolated rat cardiac fibroblasts, 17β-estradiol significantly increased collagen I and III gene expressions in male cells but decreased it in female cells. Conclusion—Women adapt to pressure overload differently from men. Less fibrosis before surgery may enable faster regression after surgery.
Erscheinungsjahr
2010
Zeitschriftentitel
Circulation
Band
122
Ausgabe
11_suppl_1
Seite(n)
S23-S28
ISSN
0009-7322
eISSN
1524-4539
Page URI
https://pub.uni-bielefeld.de/record/2964892

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Petrov G, Regitz-Zagrosek V, Lehmkuhl E, et al. Regression of Myocardial Hypertrophy After Aortic Valve Replacement. Circulation. 2010;122(11_suppl_1):S23-S28.
Petrov, G., Regitz-Zagrosek, V., Lehmkuhl, E., Krabatsch, T., Dunkel, A., Dandel, M., Dworatzek, E., et al. (2010). Regression of Myocardial Hypertrophy After Aortic Valve Replacement. Circulation, 122(11_suppl_1), S23-S28. https://doi.org/10.1161/CIRCULATIONAHA.109.927764
Petrov, George, Regitz-Zagrosek, Vera, Lehmkuhl, Elke, Krabatsch, Thomas, Dunkel, Anne, Dandel, Michael, Dworatzek, Elke, et al. 2010. “Regression of Myocardial Hypertrophy After Aortic Valve Replacement”. Circulation 122 (11_suppl_1): S23-S28.
Petrov, G., Regitz-Zagrosek, V., Lehmkuhl, E., Krabatsch, T., Dunkel, A., Dandel, M., Dworatzek, E., Mahmoodzadeh, S., Schubert, C., Becher, E., et al. (2010). Regression of Myocardial Hypertrophy After Aortic Valve Replacement. Circulation 122, S23-S28.
Petrov, G., et al., 2010. Regression of Myocardial Hypertrophy After Aortic Valve Replacement. Circulation, 122(11_suppl_1), p S23-S28.
G. Petrov, et al., “Regression of Myocardial Hypertrophy After Aortic Valve Replacement”, Circulation, vol. 122, 2010, pp. S23-S28.
Petrov, G., Regitz-Zagrosek, V., Lehmkuhl, E., Krabatsch, T., Dunkel, A., Dandel, M., Dworatzek, E., Mahmoodzadeh, S., Schubert, C., Becher, E., Hampl, H., Hetzer, R.: Regression of Myocardial Hypertrophy After Aortic Valve Replacement. Circulation. 122, S23-S28 (2010).
Petrov, George, Regitz-Zagrosek, Vera, Lehmkuhl, Elke, Krabatsch, Thomas, Dunkel, Anne, Dandel, Michael, Dworatzek, Elke, Mahmoodzadeh, Shokoufeh, Schubert, Carola, Becher, Eva, Hampl, Hannah, and Hetzer, Roland. “Regression of Myocardial Hypertrophy After Aortic Valve Replacement”. Circulation 122.11_suppl_1 (2010): S23-S28.

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