Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1)

Scholzen T, Hartmeyer M, Fastrich M, Brzoska T, Becher E, Schwarz T, Luger TA (1998)
Journal of Investigative Dermatology 111(1): 50-56.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Scholzen, Thomas; Hartmeyer, Mechthild; Fastrich, Michaela; Brzoska, Thomas; Becher, EvaUniBi ; Schwarz, Thomas; Luger, Thomas A.
Abstract / Bemerkung
Exposure of the skin to ultraviolet (UV) light causes DNA damage, inflammation, and impairment of local as well as systemic immune responses. Dermal microvascular endothelial cells are key elements for the recruitment of inflammatory cells during the pathogenesis of inflammatory skin diseases via the expression of adhesion molecules and the release of cytokines. Because WE may directly affect the function of dermal cells it was investigated whether UVB irradiation alters the production of proinflammatory and chemotactic cytokines by endothelial cells. UVB exposure of transformed human microvascular endothelial cells (HMEC-1) resulted in a dose dependently increased mRNA expression as well as release of interleukin (IL)-1 beta, IL-6, IL-8, and growth-regulated oncogene alpha (GRO alpha). Maximum cytokine production was observed 16-24 h after irradiation when 7.5-12.5 mJ UVB per cm(2) were used. In addition, it was examined whether IL-10, which is upregulated in keratinocytes following UVB irradiation and accounts for UV mediated immunosuppression such as inhibition of contact hypersensitivity, also affects endothelial cell cytokine production. Treatment of HMEC-1 with IL-10 significantly enhanced IE-g and IL-8 release and further upregulated UVB-induced IL-6 and IL-8 mRNA expression. These findings demonstrate that UVB both directly and indirectly via I-he release of IL-10 stimulates microvascular endothelial cells to produce proinflammatory cytokines and chemokines that are required for the migration and activation of inflammatory cells in UV-mediated inflammatory skin reactions.
Erscheinungsjahr
1998
Zeitschriftentitel
Journal of Investigative Dermatology
Band
111
Ausgabe
1
Seite(n)
50-56
ISSN
0022-202X
Page URI
https://pub.uni-bielefeld.de/record/2964886

Zitieren

Scholzen T, Hartmeyer M, Fastrich M, et al. Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1). Journal of Investigative Dermatology. 1998;111(1):50-56.
Scholzen, T., Hartmeyer, M., Fastrich, M., Brzoska, T., Becher, E., Schwarz, T., & Luger, T. A. (1998). Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1). Journal of Investigative Dermatology, 111(1), 50-56. https://doi.org/10.1046/j.1523-1747.1998.00229.x
Scholzen, T., Hartmeyer, M., Fastrich, M., Brzoska, T., Becher, E., Schwarz, T., and Luger, T. A. (1998). Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1). Journal of Investigative Dermatology 111, 50-56.
Scholzen, T., et al., 1998. Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1). Journal of Investigative Dermatology, 111(1), p 50-56.
T. Scholzen, et al., “Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1)”, Journal of Investigative Dermatology, vol. 111, 1998, pp. 50-56.
Scholzen, T., Hartmeyer, M., Fastrich, M., Brzoska, T., Becher, E., Schwarz, T., Luger, T.A.: Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1). Journal of Investigative Dermatology. 111, 50-56 (1998).
Scholzen, Thomas, Hartmeyer, Mechthild, Fastrich, Michaela, Brzoska, Thomas, Becher, Eva, Schwarz, Thomas, and Luger, Thomas A. “Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1)”. Journal of Investigative Dermatology 111.1 (1998): 50-56.

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