Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R

Becher E, MAHNKE K, BRZOSKA T, KALDEN D-H, GRABBE S, LUGER TA (1999)
Annals of the New York Academy of Sciences 885(1): 188-195.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Becher, EvaUniBi ; MAHNKE, K.; BRZOSKA, T.; KALDEN, D.-H.; GRABBE, S.; LUGER, T. A.
Abstract / Bemerkung
The neuropeptide, α-melanocyte-stimulating hormone (α-MSH) is well known for its immunomodulating capabilities. α-MSH antagonizes the activity of numerous proinflammatory mediators; for example, Interleukin-1 (IL-1), IL-6, tumor necrosis factor α (TNFα), and bacterial endotoxin. In vivoα-MSH has been shown to suppress a contact hypersensitivity reaction in mice, and to induce hapten-specific tolerance. Since antigen presenting cells (APC) represent key elements for tolerance induction, the effect of α-MSH, and the expression of its receptor-melanocortin receptor-1 (MC-1R), on human peripheral blood-derived monocytes and dendritic cells (DC), was investigated. Semiquantitative RT-PCR demonstrated that monocytes and DC express MC-1R, but none of the other members of the MC-receptor family. Moreover, the extent of MC-1R expression correlated with the state of activation of these cells. Since the major ligand of MC-1R is α-MSH the question of whether α-MSH affects the function of monocyte derived DC was further investigated. We found that the expression of the costimulatory molecules CD 86 and CD 40 was downregulated on DC in the presence of α-MSH. Thus, α-MSH may exert its immunosuppressive effects by altering the function of APC.
Erscheinungsjahr
1999
Zeitschriftentitel
Annals of the New York Academy of Sciences
Band
885
Ausgabe
1
Seite(n)
188-195
ISSN
0077-8923
eISSN
1749-6632
Page URI
https://pub.uni-bielefeld.de/record/2964883

Zitieren

Becher E, MAHNKE K, BRZOSKA T, KALDEN D-H, GRABBE S, LUGER TA. Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R. Annals of the New York Academy of Sciences. 1999;885(1):188-195.
Becher, E., MAHNKE, K., BRZOSKA, T., KALDEN, D. - H., GRABBE, S., & LUGER, T. A. (1999). Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R. Annals of the New York Academy of Sciences, 885(1), 188-195. https://doi.org/10.1111/j.1749-6632.1999.tb08676.x
Becher, E., MAHNKE, K., BRZOSKA, T., KALDEN, D. - H., GRABBE, S., and LUGER, T. A. (1999). Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R. Annals of the New York Academy of Sciences 885, 188-195.
Becher, E., et al., 1999. Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R. Annals of the New York Academy of Sciences, 885(1), p 188-195.
E. Becher, et al., “Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R”, Annals of the New York Academy of Sciences, vol. 885, 1999, pp. 188-195.
Becher, E., MAHNKE, K., BRZOSKA, T., KALDEN, D.-H., GRABBE, S., LUGER, T.A.: Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R. Annals of the New York Academy of Sciences. 885, 188-195 (1999).
Becher, Eva, MAHNKE, K., BRZOSKA, T., KALDEN, D.-H., GRABBE, S., and LUGER, T. A. “Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R”. Annals of the New York Academy of Sciences 885.1 (1999): 188-195.

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