Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia

Minnerup J, Heidrich J, Wellmann J, Rogalewski A, Schneider A, Schäbitz W-R (2008)
Stroke 39(6): 1855-1861.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Minnerup, Jens; Heidrich, Jan; Wellmann, Jürgen; Rogalewski, AndreasUniBi ; Schneider, Armin; Schäbitz, Wolf-RüdigerUniBi
Abstract / Bemerkung
Background and Purpose—Recent reports have described the efficacy of the hematopoietic growth factor granulocyte-colony stimulating factor (G-CSF) in animal stroke models. Early clinical multicenter trials evaluating the effect of G-CSF in acute stroke and pilot clinical trials for the subacute phase are ongoing. To guide further development, a meta-analysis was performed to assess the effects of G-CSF on infarct size and sensorimotor deficits.
Methods—Using electronic and manual searches of the literature, we identified studies describing the efficacy of G-CSF in animal models of focal cerebral ischemia. Two reviewers independently selected studies and extracted data on study quality, G-CSF doses, time of administration, and outcome measured as infarct volume and/or sensorimotor deficit. Data from all studies were pooled by meta-regression analyses.
Results—Thirteen studies including 277 animals for infarct size calculation and 258 animals for assessment of sensorimotor deficit met the criteria for inclusion. Overall efficacy of G-CSF regarding infarct size reduction was 42%. Meta-regression analysis revealed a 0.8% (P<0.0001) decrease in infarct size per 1-μg/kg increase in G-CSF dose when applied within the first 6 hours and a 2.1% (P<0.0001) decrease when applied later than 6 hours after induction of ischemia with a significant (P=0.0004) greater infarct size reduction after delayed treatment. Sensorimotor deficits categorized into 3 subgroups improved between 24% and 40%.
Conclusions—Our findings consolidate G-CSF as a drug that both reduces infarct size and enhances functional recovery. These effects are presumably dose dependent. In contrast to most other neuroprotectants, a beneficial outcome may also be achieved when treatment is delayed.
Erscheinungsjahr
2008
Zeitschriftentitel
Stroke
Band
39
Ausgabe
6
Seite(n)
1855-1861
ISSN
0039-2499
eISSN
1524-4628
Page URI
https://pub.uni-bielefeld.de/record/2964862

Zitieren

Minnerup J, Heidrich J, Wellmann J, Rogalewski A, Schneider A, Schäbitz W-R. Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia. Stroke. 2008;39(6):1855-1861.
Minnerup, J., Heidrich, J., Wellmann, J., Rogalewski, A., Schneider, A., & Schäbitz, W. - R. (2008). Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia. Stroke, 39(6), 1855-1861. https://doi.org/10.1161/STROKEAHA.107.506816
Minnerup, J., Heidrich, J., Wellmann, J., Rogalewski, A., Schneider, A., and Schäbitz, W. - R. (2008). Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia. Stroke 39, 1855-1861.
Minnerup, J., et al., 2008. Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia. Stroke, 39(6), p 1855-1861.
J. Minnerup, et al., “Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia”, Stroke, vol. 39, 2008, pp. 1855-1861.
Minnerup, J., Heidrich, J., Wellmann, J., Rogalewski, A., Schneider, A., Schäbitz, W.-R.: Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia. Stroke. 39, 1855-1861 (2008).
Minnerup, Jens, Heidrich, Jan, Wellmann, Jürgen, Rogalewski, Andreas, Schneider, Armin, and Schäbitz, Wolf-Rüdiger. “Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia”. Stroke 39.6 (2008): 1855-1861.
Link(s) zu Volltext(en)
Access Level
Restricted Closed Access

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 18403735
PubMed | Europe PMC

Suchen in

Google Scholar