Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)

Leutcha BP, Dzoyem JP, Jouda J-B, Sema DK, Tsague Tankeu VF, Bitchagno GTM, Tchegnitegni BT, Essoung FRE, Ndjakou Lenta B, Fogue Kouam S, Delie F, et al. (2022)
Molecules 27(15): 4823.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Leutcha, Bosco Peron; Dzoyem, Jean Paul; Jouda, Jean-Bosco; Sema, Denis Kehdinga; Tsague Tankeu, Virginie Flaure; Bitchagno, Gabin Thierry Mbahbou; Tchegnitegni, Billy Toussie; Essoung, Flaure Rosette Ehawa; Ndjakou Lenta, Bruno; Fogue Kouam, Siméon; Delie, Florence; Meli Lannang, Alain
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Abstract / Bemerkung
Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC50 values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described.
Erscheinungsjahr
2022
Zeitschriftentitel
Molecules
Band
27
Ausgabe
15
Art.-Nr.
4823
eISSN
1420-3049
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Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2964817

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Leutcha BP, Dzoyem JP, Jouda J-B, et al. Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules. 2022;27(15): 4823.
Leutcha, B. P., Dzoyem, J. P., Jouda, J. - B., Sema, D. K., Tsague Tankeu, V. F., Bitchagno, G. T. M., Tchegnitegni, B. T., et al. (2022). Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules, 27(15), 4823. https://doi.org/10.3390/molecules27154823
Leutcha, B. P., Dzoyem, J. P., Jouda, J. - B., Sema, D. K., Tsague Tankeu, V. F., Bitchagno, G. T. M., Tchegnitegni, B. T., Essoung, F. R. E., Ndjakou Lenta, B., Fogue Kouam, S., et al. (2022). Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules 27:4823.
Leutcha, B.P., et al., 2022. Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules, 27(15): 4823.
B.P. Leutcha, et al., “Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)”, Molecules, vol. 27, 2022, : 4823.
Leutcha, B.P., Dzoyem, J.P., Jouda, J.-B., Sema, D.K., Tsague Tankeu, V.F., Bitchagno, G.T.M., Tchegnitegni, B.T., Essoung, F.R.E., Ndjakou Lenta, B., Fogue Kouam, S., Delie, F., Meli Lannang, A., Sewald, N.: Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules. 27, : 4823 (2022).
Leutcha, Bosco Peron, Dzoyem, Jean Paul, Jouda, Jean-Bosco, Sema, Denis Kehdinga, Tsague Tankeu, Virginie Flaure, Bitchagno, Gabin Thierry Mbahbou, Tchegnitegni, Billy Toussie, Essoung, Flaure Rosette Ehawa, Ndjakou Lenta, Bruno, Fogue Kouam, Siméon, Delie, Florence, Meli Lannang, Alain, and Sewald, Norbert. “Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)”. Molecules 27.15 (2022): 4823.
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2022-08-02T06:27:43Z
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