Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial

del Cura-Gonzalez I, Lopez-Rodriguez JA, Leiva-Fernandez F, Gimeno-Feliu LA, Pico-Soler V, Josefa Bujalance-Zafra M, Dominguez-Santaella M, Polentinos-Castro E, Poblador-Plou B, Ara-Bardaji P, Aza-Pascual-Salcedo M, et al. (2022)
Trials 23(1): 479.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
del Cura-Gonzalez, Isabel; Lopez-Rodriguez, Juan A.; Leiva-Fernandez, Francisca; Gimeno-Feliu, Luis A.; Pico-Soler, Victoria; Josefa Bujalance-Zafra, Ma; Dominguez-Santaella, Miguel; Polentinos-Castro, Elena; Poblador-Plou, Beatriz; Ara-Bardaji, Paula; Aza-Pascual-Salcedo, Mercedes; Rogero-Blanco, Marisa
Alle
Abstract / Bemerkung
Background: The progressive ageing of the population is leading to an increase in multimorbidity and polypharmacy, which in turn may increase the risk of hospitalization and mortality. The enhancement of care with information and communications technology (ICT) can facilitate the use of prescription evaluation tools and support system for decision-making (DSS) with the potential of optimizing the healthcare delivery process. Objective: To assess the effectiveness and cost-effectiveness of the complex intervention MULTIPAP Plus, compared to usual care, in improving prescriptions for young-old patients (65-74 years old) with multimorbidity and polypharmacy in primary care. Methods/design: This is a pragmatic cluster-randomized clinical trial with a follow-up of 18 months in health centres of the Spanish National Health System. Unit of randomization: family physician. Unit of analysis: patient. Population: Patients aged 65-74 years with multimorbidity (>= 3 chronic diseases) and polypharmacy (>= 5 drugs) during the previous 3 months were included. Sample size: n = 1148 patients (574 per study arm). Intervention: Complex intervention based on the ARIADNE principles with three components: (1) family physician (FP) training, (2) FP-patient interview, and (3) decision-making support system. Outcomes: The primary outcome is a composite endpoint of hospital admission or death during the observation period measured as a binary outcome, and the secondary outcomes are number of hospital admission, all-cause mortality, use of health services, quality of life (EQ-5D-5L), functionality (WHODAS), falls, hip fractures, prescriptions and adherence to treatment. Clinical and sociodemographic factors will be explanatory variables. Statistical analysis: The main result is the difference in percentages in the final composite endpoint variable at 18 months, with its corresponding 95% CI. Adjustments by the main confounding and prognostic factors will be performed through a multilevel analysis. All analyses will be carried out in accordance to the intention-to-treat principle. Discussion: It is important to prevent the cascade of negative health and health care impacts attributable to the multimorbidity-polypharmacy binomial. ICT-enhanced routine clinical practice could improve the prescription process in patient care.
Stichworte
Multimorbidity; Patient-centred care; Polypharmacy; Medication; reconciliation; Decision-making; Computer assisted; Primary health care; Cluster randomized controlled trial
Erscheinungsjahr
2022
Zeitschriftentitel
Trials
Band
23
Ausgabe
1
Art.-Nr.
479
eISSN
1745-6215
Page URI
https://pub.uni-bielefeld.de/record/2964071

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del Cura-Gonzalez I, Lopez-Rodriguez JA, Leiva-Fernandez F, et al. Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials. 2022;23(1): 479.
del Cura-Gonzalez, I., Lopez-Rodriguez, J. A., Leiva-Fernandez, F., Gimeno-Feliu, L. A., Pico-Soler, V., Josefa Bujalance-Zafra, M., Dominguez-Santaella, M., et al. (2022). Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials, 23(1), 479. https://doi.org/10.1186/s13063-022-06293-x
del Cura-Gonzalez, I., Lopez-Rodriguez, J. A., Leiva-Fernandez, F., Gimeno-Feliu, L. A., Pico-Soler, V., Josefa Bujalance-Zafra, M., Dominguez-Santaella, M., Polentinos-Castro, E., Poblador-Plou, B., Ara-Bardaji, P., et al. (2022). Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials 23:479.
del Cura-Gonzalez, I., et al., 2022. Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials, 23(1): 479.
I. del Cura-Gonzalez, et al., “Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial”, Trials, vol. 23, 2022, : 479.
del Cura-Gonzalez, I., Lopez-Rodriguez, J.A., Leiva-Fernandez, F., Gimeno-Feliu, L.A., Pico-Soler, V., Josefa Bujalance-Zafra, M., Dominguez-Santaella, M., Polentinos-Castro, E., Poblador-Plou, B., Ara-Bardaji, P., Aza-Pascual-Salcedo, M., Rogero-Blanco, M., Castillo-Jimenez, M., Lozano-Hernandez, C., Gimeno-Miguel, A., Gonzalez-Rubio, F., Medina-Garcia, R., Gonzalez-Hevilla, A., Gil-Conesa, M., Martin-Fernandez, J., Valderas, J.M., Marengoni, A., Muth, C., Prados-Torres, J.D., Prados-Torres, A.: Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials. 23, : 479 (2022).
del Cura-Gonzalez, Isabel, Lopez-Rodriguez, Juan A., Leiva-Fernandez, Francisca, Gimeno-Feliu, Luis A., Pico-Soler, Victoria, Josefa Bujalance-Zafra, Ma, Dominguez-Santaella, Miguel, Polentinos-Castro, Elena, Poblador-Plou, Beatriz, Ara-Bardaji, Paula, Aza-Pascual-Salcedo, Mercedes, Rogero-Blanco, Marisa, Castillo-Jimenez, Marcos, Lozano-Hernandez, Cristina, Gimeno-Miguel, Antonio, Gonzalez-Rubio, Francisca, Medina-Garcia, Rodrigo, Gonzalez-Hevilla, Alba, Gil-Conesa, Mario, Martin-Fernandez, Jesus, Valderas, Jose M., Marengoni, Alessandra, Muth, Christiane, Prados-Torres, J. Daniel, and Prados-Torres, Alexandra. “Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial”. Trials 23.1 (2022): 479.

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