Cytotoxic compounds from the root bark of Securidac alongipedunculata

Wedajo F, Gure A, Meshesha M, Kedir K, Frese M, Sewald N, Abdissa Ayana N (2022)
Bulletin of the Chemical Society of Ethiopia 36(2): 417-422.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Wedajo, Feyisa; Gure, Abera; Meshesha, Melkau; Kedir, Kassim; Frese, MarcelUniBi ; Sewald, NorbertUniBi ; Abdissa Ayana, NegeraUniBi
Abstract / Bemerkung
Chromatographic separation of the ethyl acetate extract of the root bark of Securidaca longipedunculata led to the isolation of one new xanthone derivative (1) along with nine known compounds (2-10). The structure of the isolated compounds were identified by NMR, mass spectrometric analyses, and comparison with the reported literature data. The isolates were evaluated for their cytotoxic activity with compounds 5 (IC50 = 0.38 mu M) and 6 (IC50 = 52 mu M) showed significant inhibitory activities against the human cervical cancer KB-3-1 cell line. Compound 5 displayed superior activity, which is even better than one of the reference drugs (griseofulvin, IC50 = 17 mu M), whereas the rest showed little or none inhibitory activities.
Stichworte
Securidaca longipedunculata; Root bark; Xanthones; Cytotoxicity; Cervical cancer
Erscheinungsjahr
2022
Zeitschriftentitel
Bulletin of the Chemical Society of Ethiopia
Band
36
Ausgabe
2
Seite(n)
417-422
ISSN
1011-3924
eISSN
1726-801X
Page URI
https://pub.uni-bielefeld.de/record/2964063

Zitieren

Wedajo F, Gure A, Meshesha M, et al. Cytotoxic compounds from the root bark of Securidac alongipedunculata . Bulletin of the Chemical Society of Ethiopia . 2022;36(2):417-422.
Wedajo, F., Gure, A., Meshesha, M., Kedir, K., Frese, M., Sewald, N., & Abdissa Ayana, N. (2022). Cytotoxic compounds from the root bark of Securidac alongipedunculata . Bulletin of the Chemical Society of Ethiopia , 36(2), 417-422. https://doi.org/10.4314/bcse.v36i2.14
Wedajo, F., Gure, A., Meshesha, M., Kedir, K., Frese, M., Sewald, N., and Abdissa Ayana, N. (2022). Cytotoxic compounds from the root bark of Securidac alongipedunculata . Bulletin of the Chemical Society of Ethiopia 36, 417-422.
Wedajo, F., et al., 2022. Cytotoxic compounds from the root bark of Securidac alongipedunculata . Bulletin of the Chemical Society of Ethiopia , 36(2), p 417-422.
F. Wedajo, et al., “Cytotoxic compounds from the root bark of Securidac alongipedunculata ”, Bulletin of the Chemical Society of Ethiopia , vol. 36, 2022, pp. 417-422.
Wedajo, F., Gure, A., Meshesha, M., Kedir, K., Frese, M., Sewald, N., Abdissa Ayana, N.: Cytotoxic compounds from the root bark of Securidac alongipedunculata . Bulletin of the Chemical Society of Ethiopia . 36, 417-422 (2022).
Wedajo, Feyisa, Gure, Abera, Meshesha, Melkau, Kedir, Kassim, Frese, Marcel, Sewald, Norbert, and Abdissa Ayana, Negera. “Cytotoxic compounds from the root bark of Securidac alongipedunculata ”. Bulletin of the Chemical Society of Ethiopia 36.2 (2022): 417-422.

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