Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae)

Essombe Malolo F-A, Bellier Tabekoueng G, Dongmo Tekapi Tsopgni W, Nguemdjo Chimeze VW, Kenmogne Kouam A, Mas-Claret E, Langat MK, Ndom JC, Frese M, Sewald N, Duplex Wansi J (2022)
Chemistry & biodiversity: e202101033.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Essombe Malolo, Fanny-Aimee; Bellier Tabekoueng, George; Dongmo Tekapi Tsopgni, Willifred; Nguemdjo Chimeze, Valery Wilfried; Kenmogne Kouam, Ariane; Mas-Claret, Eduard; Langat, Moses K; Ndom, Jean Claude; Frese, MarcelUniBi ; Sewald, NorbertUniBi ; Duplex Wansi, Jean
Abstract / Bemerkung
The stem bark of Citrus * paradisi Macfad. (Rutaceae) gave (23S)-isolimonexic acid (1), limonin (2), citracridone II (3), citpressine II (4), citpressine I (5), grandisine (6), 2-hydroxynoracronycine (7), citracridone I (8), 5-methoxyseselin (9), umbelliferone (10), scopoletin (11), naringenin (12), apigenin (13), friedelin (14), agrostophyllinone (15) and stigmasterol-3-O-beta-D-glucopyranoside (16). The structures of the compounds were determined using NMR and MS spectroscopic data, and by comparison with published data. The relative configuration of 1 was proposed as (23S)-isolimonexic acid using NOE studies. Hydrogenation reaction of compound 3 led to the new derivative 3',4'-dihydrocitracridone II (3a). Cytotoxicity activities against the human adenocarcinoma alveolar basal epithelial cell lines A549 and the Caucasian prostate adenocarcinoma cell lines PC3, using the MTT assays showed that the methanol crude extract was significant with IC50 values of 30.1 and 31.7 mug/mL, respectively, with the positive control, doxorubicin giving an IC50 of 0.9 muM. In addition, compounds 3, 7 and 8 gave moderate cytotoxic activities with IC50 values of 33.1, 31.2 and 32.5 muM for A549 cells and 35.7, 33.8 and 34.9 muM for PC3 cells, respectively. The hydrogenated 3a was less active than 3, suggesting that the presence of the double bond in pyrans is important for structure-activity relationship. © 2022 Wiley-VHCA AG, Zurich, Switzerland.
Erscheinungsjahr
2022
Zeitschriftentitel
Chemistry & biodiversity
Art.-Nr.
e202101033
ISSN
1612-1880
Page URI
https://pub.uni-bielefeld.de/record/2963955

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Essombe Malolo F-A, Bellier Tabekoueng G, Dongmo Tekapi Tsopgni W, et al. Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae). Chemistry & biodiversity. 2022: e202101033.
Essombe Malolo, F. - A., Bellier Tabekoueng, G., Dongmo Tekapi Tsopgni, W., Nguemdjo Chimeze, V. W., Kenmogne Kouam, A., Mas-Claret, E., Langat, M. K., et al. (2022). Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae). Chemistry & biodiversity, e202101033. https://doi.org/10.1002/cbdv.202101033
Essombe Malolo, F. - A., Bellier Tabekoueng, G., Dongmo Tekapi Tsopgni, W., Nguemdjo Chimeze, V. W., Kenmogne Kouam, A., Mas-Claret, E., Langat, M. K., Ndom, J. C., Frese, M., Sewald, N., et al. (2022). Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae). Chemistry & biodiversity:e202101033.
Essombe Malolo, F.-A., et al., 2022. Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae). Chemistry & biodiversity, : e202101033.
F.-A. Essombe Malolo, et al., “Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae)”, Chemistry & biodiversity, 2022, : e202101033.
Essombe Malolo, F.-A., Bellier Tabekoueng, G., Dongmo Tekapi Tsopgni, W., Nguemdjo Chimeze, V.W., Kenmogne Kouam, A., Mas-Claret, E., Langat, M.K., Ndom, J.C., Frese, M., Sewald, N., Duplex Wansi, J.: Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae). Chemistry & biodiversity. : e202101033 (2022).
Essombe Malolo, Fanny-Aimee, Bellier Tabekoueng, George, Dongmo Tekapi Tsopgni, Willifred, Nguemdjo Chimeze, Valery Wilfried, Kenmogne Kouam, Ariane, Mas-Claret, Eduard, Langat, Moses K, Ndom, Jean Claude, Frese, Marcel, Sewald, Norbert, and Duplex Wansi, Jean. “Chemical Constituents of the Stem Bark of the Hybrid Plant Citrus * paradisi Macfad. (Rutaceae)”. Chemistry & biodiversity (2022): e202101033.

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