Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia

Jönsson EG, Cichon S, Schumacher J, Jamra RA, Schulze TG, Deschner M, Forslund K, Hall H, Propping P, Czerski PM, Dmitrak-Weglarz M, et al. (2006)
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(1): 71-75.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Jönsson, Erik G.; Cichon, Sven; Schumacher, Johannes; Jamra, Rami Abou; Schulze, Thomas G.; Deschner, Monica; Forslund, Kaj; Hall, Håkan; Propping, Peter; Czerski, Piotr M.; Dmitrak-Weglarz, Monica; Kapelski, Pawel
Alle
Abstract / Bemerkung
A functional promoter polymorphism (−116C/G) of the X-box binding protein 1 gene (XBP1) gene was reported to be associated with schizophrenia in Asian subjects. In a replication attempt, three European case-control samples comprising 2,182 German, Polish, and Swedish subjects, were genotyped for the XBP1 −116C/G polymorphism. Allele and genotype frequencies were compared between schizophrenic patients and control subjects. There were no significant case-control differences in any of the three samples, although in a meta-analysis with previous results comprising 3,612 subjects there was a borderline association between the −116G-containing genotypes and schizophrenia. We conclude that the functional XBP1 gene polymorphism is not of major importance to schizophrenia in the European populations investigated. It cannot be excluded, however, that the XBP1 polymorphism is involved in schizophrenia in other populations or adds minor susceptibility to the disorder.
Erscheinungsjahr
2006
Zeitschriftentitel
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Band
141B
Ausgabe
1
Seite(n)
71-75
ISSN
1552-4841
eISSN
1552-485X
Page URI
https://pub.uni-bielefeld.de/record/2963402

Zitieren

Jönsson EG, Cichon S, Schumacher J, et al. Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2006;141B(1):71-75.
Jönsson, E. G., Cichon, S., Schumacher, J., Jamra, R. A., Schulze, T. G., Deschner, M., Forslund, K., et al. (2006). Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B(1), 71-75. https://doi.org/10.1002/ajmg.b.30262
Jönsson, E. G., Cichon, S., Schumacher, J., Jamra, R. A., Schulze, T. G., Deschner, M., Forslund, K., Hall, H., Propping, P., Czerski, P. M., et al. (2006). Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B, 71-75.
Jönsson, E.G., et al., 2006. Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B(1), p 71-75.
E.G. Jönsson, et al., “Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia”, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 141B, 2006, pp. 71-75.
Jönsson, E.G., Cichon, S., Schumacher, J., Jamra, R.A., Schulze, T.G., Deschner, M., Forslund, K., Hall, H., Propping, P., Czerski, P.M., Dmitrak-Weglarz, M., Kapelski, P., Driessen, M., Maier, W., Hauser, J., Rietschel, M., Nöthen, M.M.: Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 141B, 71-75 (2006).
Jönsson, Erik G., Cichon, Sven, Schumacher, Johannes, Jamra, Rami Abou, Schulze, Thomas G., Deschner, Monica, Forslund, Kaj, Hall, Håkan, Propping, Peter, Czerski, Piotr M., Dmitrak-Weglarz, Monica, Kapelski, Pawel, Driessen, Martin, Maier, Wolfgang, Hauser, Joanna, Rietschel, Marcella, and Nöthen, Markus M. “Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia”. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B.1 (2006): 71-75.

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