Early detection of Alzheimer's disease: a new working memory paradigm

Toepper M, Beblo T, Thomas C, Driessen M (2008)
International Journal of Geriatric Psychiatry 23(3): 272-278.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Toepper, Max; Beblo, ThomasUniBi; Thomas, Christine; Driessen, MartinUniBi
Abstract / Bemerkung
Objectives Early detection of Alzheimer's disease (AD) offers the chance to decelerate the patients' cognitive decline and to prolong a self-determined, independent life. Neuropsychological testing is one key approach to establish an early diagnosis. Whereas more global cognitive abilities can be preserved until further progression of the disease, specific executive abilities such as dual-task or active inhibition processes decline very early. Our recently developed working memory paradigm, the Block Suppression Test (BST), requires an active inhibition of irrelevant stimuli and thus should differentiate between Alzheimer patients and controls in early disease stages more accurately than classical screening instruments. Methods In a pilot study we applied the BST, the MMSE, the clock drawing test, a digit-word transformation task as well as verbal and spatial memory span tasks to a group of 13 patients with Alzheimer's disease and 13 elderly controls and compared the instruments' capability to differentiate between patients and controls. Results The BST showed the highest sensitivity among all applied tests with a perfect differentiation of healthy subjects and patients. The patients' backward spans were significantly reduced, in the inhibition condition they showed disproportionally worse performances. Conclusions Our results reveal a specific inhibition deficit in mild AD rather than a global working memory breakdown. The BST thus was superior for early diagnosis. However, these findings must be replicated in a larger sample to prove the BST's applicability for the early diagnostic assessment of AD and other dementias.
Erscheinungsjahr
2008
Zeitschriftentitel
International Journal of Geriatric Psychiatry
Band
23
Ausgabe
3
Seite(n)
272-278
ISSN
0885-6230
eISSN
1099-1166
Page URI
https://pub.uni-bielefeld.de/record/2963396

Zitieren

Toepper M, Beblo T, Thomas C, Driessen M. Early detection of Alzheimer's disease: a new working memory paradigm. International Journal of Geriatric Psychiatry. 2008;23(3):272-278.
Toepper, M., Beblo, T., Thomas, C., & Driessen, M. (2008). Early detection of Alzheimer's disease: a new working memory paradigm. International Journal of Geriatric Psychiatry, 23(3), 272-278. https://doi.org/10.1002/gps.1873
Toepper, M., Beblo, T., Thomas, C., and Driessen, M. (2008). Early detection of Alzheimer's disease: a new working memory paradigm. International Journal of Geriatric Psychiatry 23, 272-278.
Toepper, M., et al., 2008. Early detection of Alzheimer's disease: a new working memory paradigm. International Journal of Geriatric Psychiatry, 23(3), p 272-278.
M. Toepper, et al., “Early detection of Alzheimer's disease: a new working memory paradigm”, International Journal of Geriatric Psychiatry, vol. 23, 2008, pp. 272-278.
Toepper, M., Beblo, T., Thomas, C., Driessen, M.: Early detection of Alzheimer's disease: a new working memory paradigm. International Journal of Geriatric Psychiatry. 23, 272-278 (2008).
Toepper, Max, Beblo, Thomas, Thomas, Christine, and Driessen, Martin. “Early detection of Alzheimer's disease: a new working memory paradigm”. International Journal of Geriatric Psychiatry 23.3 (2008): 272-278.

9 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Are There Any Connections between Language Deficits and Cognitive Slowing in Alzheimer's Disease?
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PMID: 25538728
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Toepper M, Steuwe C, Beblo T, Bauer E, Boedeker S, Thomas C, Markowitsch HJ, Driessen M, Sammer G., Alzheimer Dis Assoc Disord 28(4), 2014
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The block suppression test uncovers specific inhibitory deficits in mild cognitive impairment.
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PMID: 22333920
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Friedman TW, Yelland GW, Robinson SR., Int J Geriatr Psychiatry 27(5), 2012
PMID: 21626569

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