Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines

Stein M, Dietrich D, Agelink M, Becker W, Chrysanthou C, Driessen M, Kruse G, Machleidt W, Reker T, Schneider U, Schulze Mönking H, et al. (2012)
Pharmacopsychiatry 45(5): 189-195.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Stein, M.; Dietrich, D.; Agelink, M.; Becker, W.; Chrysanthou, C.; Driessen, MartinUniBi ; Kruse, G.; Machleidt, W.; Reker, T.; Schneider, U.; Schulze Mönking, H.; Emrich, H.
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Abstract / Bemerkung
Introduction: This study was designed to investigate to what extent guidelines regarding the pharmacological treatment of patients suffering from schizophrenia-like psychosis are adopted in a naturalistic treatment setting. Methods: Medical records of n=819 patients undergoing inpatient treatment for schizophrenia-like psychosis in 11 psychiatric hospitals in northwestern Germany were retrospectively analyzed and findings were compared to current schizophrenia guideline recommendations. Results: The prescription rate of second generation antipsychotics increased from 47.1% on admission to 62.5% at discharge. Only half the patients (52.3%) received antipsychotic monotherapy while 47.7% took between 2 and 4 antipsychotic substances at a time. Dosage increases occurred most frequently (in 60%) within the first week of inpatient treatment, 16.6% experienced an elevation between days 15 and 29. A change within the atypical medication was found in 19.3%. Clozapine prescriptions increased throughout the treatment but were combined with other antipsychotic substances in the majority of cases. Conclusion: Under naturalistic conditions guideline recommendations for treatment of schizophrenia-like psychosis are adhered to only partially. Combination therapy with 2 or more antipsychotic drugs is quite common despite a clear recommendation for monotherapy.
Erscheinungsjahr
2012
Zeitschriftentitel
Pharmacopsychiatry
Band
45
Ausgabe
5
Seite(n)
189-195
ISSN
0176-3679
eISSN
1439-0795
Page URI
https://pub.uni-bielefeld.de/record/2963372

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Stein M, Dietrich D, Agelink M, et al. Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines. Pharmacopsychiatry. 2012;45(5):189-195.
Stein, M., Dietrich, D., Agelink, M., Becker, W., Chrysanthou, C., Driessen, M., Kruse, G., et al. (2012). Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines. Pharmacopsychiatry, 45(5), 189-195. https://doi.org/10.1055/s-0031-1301286
Stein, M., Dietrich, D., Agelink, M., Becker, W., Chrysanthou, C., Driessen, M., Kruse, G., Machleidt, W., Reker, T., Schneider, U., et al. (2012). Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines. Pharmacopsychiatry 45, 189-195.
Stein, M., et al., 2012. Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines. Pharmacopsychiatry, 45(5), p 189-195.
M. Stein, et al., “Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines”, Pharmacopsychiatry, vol. 45, 2012, pp. 189-195.
Stein, M., Dietrich, D., Agelink, M., Becker, W., Chrysanthou, C., Driessen, M., Kruse, G., Machleidt, W., Reker, T., Schneider, U., Schulze Mönking, H., Emrich, H., Arolt, V., Rothermundt, M.: Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines. Pharmacopsychiatry. 45, 189-195 (2012).
Stein, M., Dietrich, D., Agelink, M., Becker, W., Chrysanthou, C., Driessen, Martin, Kruse, G., Machleidt, W., Reker, T., Schneider, U., Schulze Mönking, H., Emrich, H., Arolt, V., and Rothermundt, M. “Naturalistic Pharmacotherapy of Acute Episodes of Schizophrenic Disorders in Comparison to Treatment Guidelines”. Pharmacopsychiatry 45.5 (2012): 189-195.

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