Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD

Wingenfeld K, Driessen M, Terfehr K, Schlosser N, Fernando SC, Otte C, Beblo T, Spitzer C, Löwe B, Wolf OT (2012)
Psychoneuroendocrinology 37(7): 1048-1056.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Wingenfeld, Katja; Driessen, MartinUniBi ; Terfehr, Kirsten; Schlosser, Nicole; Fernando, Silvia Carvalho; Otte, Christian; Beblo, Thomas; Spitzer, Carsten; Löwe, Bernd; Wolf, Oliver Tobias
Abstract / Bemerkung
Background In the present study, we aimed to compare the effect of exogenous cortisol on memory retrieval in posttraumatic stress disorder (PTSD) with the effects in healthy controls. In healthy participants, administration of cortisol impairs declarative memory retrieval. Only a few studies have investigated these effects in PTSD yielding mixed results. Methods In a placebo-controlled crossover study, 44 patients with PTSD and 65 healthy controls received either placebo or 10 mg of hydrocortisone orally before memory testing. In addition to declarative memory retrieval (word list learning), we also tested autobiographical memory retrieval specificity. Results In both tasks opposing effects of cortisol on memory were observed when comparing patients with controls. In controls, cortisol had impairing effects on memory retrieval, while in PTSD patients cortisol had enhancing effects on memory retrieval in both memory domains. Conclusions The present results suggest beneficial effects of acute cortisol elevations on hippocampal mediated memory processes in PTSD. Possible neurobiological mechanisms underlying these findings are discussed.
Erscheinungsjahr
2012
Zeitschriftentitel
Psychoneuroendocrinology
Band
37
Ausgabe
7
Seite(n)
1048-1056
ISSN
0306-4530
Page URI
https://pub.uni-bielefeld.de/record/2963370

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Wingenfeld K, Driessen M, Terfehr K, et al. Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD. Psychoneuroendocrinology. 2012;37(7):1048-1056.
Wingenfeld, K., Driessen, M., Terfehr, K., Schlosser, N., Fernando, S. C., Otte, C., Beblo, T., et al. (2012). Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD. Psychoneuroendocrinology, 37(7), 1048-1056. https://doi.org/10.1016/j.psyneuen.2011.12.002
Wingenfeld, K., Driessen, M., Terfehr, K., Schlosser, N., Fernando, S. C., Otte, C., Beblo, T., Spitzer, C., Löwe, B., and Wolf, O. T. (2012). Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD. Psychoneuroendocrinology 37, 1048-1056.
Wingenfeld, K., et al., 2012. Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD. Psychoneuroendocrinology, 37(7), p 1048-1056.
K. Wingenfeld, et al., “Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD”, Psychoneuroendocrinology, vol. 37, 2012, pp. 1048-1056.
Wingenfeld, K., Driessen, M., Terfehr, K., Schlosser, N., Fernando, S.C., Otte, C., Beblo, T., Spitzer, C., Löwe, B., Wolf, O.T.: Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD. Psychoneuroendocrinology. 37, 1048-1056 (2012).
Wingenfeld, Katja, Driessen, Martin, Terfehr, Kirsten, Schlosser, Nicole, Fernando, Silvia Carvalho, Otte, Christian, Beblo, Thomas, Spitzer, Carsten, Löwe, Bernd, and Wolf, Oliver Tobias. “Cortisol has enhancing, rather than impairing effects on memory retrieval in PTSD”. Psychoneuroendocrinology 37.7 (2012): 1048-1056.

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