Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression

Carvalho Fernando S, Beblo T, Schlosser N, Terfehr K, Otte C, Löwe B, Wolf OT, Spitzer C, Driessen M, Wingenfeld K (2012)
Psychoneuroendocrinology 37(10): 1659-1668.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Carvalho Fernando, Silvia; Beblo, Thomas; Schlosser, Nicole; Terfehr, Kirsten; Otte, Christian; Löwe, Bernd; Wolf, Oliver Tobias; Spitzer, Carsten; Driessen, MartinUniBi ; Wingenfeld, Katja
Abstract / Bemerkung
Background Alterations of the hypothalamus-pituitary-adrenal (HPA) axis are hallmarks in major depressive disorder (MDD) and there is some evidence about similar patterns in borderline personality disorder (BPD). This study examines HPA axis abnormalities with respect to clinical characteristics in both BPD (n = 24) and MDD patients (n = 33) as well as in healthy control participants (n = 41). Method A 0.5 mg dexamethasone suppression test was administered to evaluate basal cortisol release and HPA feedback sensitivity via salivary cortisol. Traumatic experiences in childhood as well as severity of borderline and depressive symptom severity and dissociation were obtained by self-report questionnaires. Results Compared to the healthy control group, BPD and MDD patients exhibited both enhanced cortisol concentrations before and after the administration of 0.5 mg dexamethasone. Higher cortisol levels were positively correlated to a history of childhood trauma, current dissociative symptoms and severity of borderline and depressive symptoms. Regression analyses revealed that some aspects of early trauma were associated with cortisol release before and after dexamethasone, whereas psychopathology did not contribute to the regression model. Conclusions HPA dysfunctions appear to be related rather to childhood trauma than to psychopathology in adulthood. Exposure to childhood trauma may contribute to long-lasting alterations in HPA activity and might enhance the risk for the development of later mental disorder.
Erscheinungsjahr
2012
Zeitschriftentitel
Psychoneuroendocrinology
Band
37
Ausgabe
10
Seite(n)
1659-1668
ISSN
0306-4530
Page URI
https://pub.uni-bielefeld.de/record/2963369

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Carvalho Fernando S, Beblo T, Schlosser N, et al. Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. Psychoneuroendocrinology. 2012;37(10):1659-1668.
Carvalho Fernando, S., Beblo, T., Schlosser, N., Terfehr, K., Otte, C., Löwe, B., Wolf, O. T., et al. (2012). Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. Psychoneuroendocrinology, 37(10), 1659-1668. https://doi.org/10.1016/j.psyneuen.2012.02.012
Carvalho Fernando, S., Beblo, T., Schlosser, N., Terfehr, K., Otte, C., Löwe, B., Wolf, O. T., Spitzer, C., Driessen, M., and Wingenfeld, K. (2012). Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. Psychoneuroendocrinology 37, 1659-1668.
Carvalho Fernando, S., et al., 2012. Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. Psychoneuroendocrinology, 37(10), p 1659-1668.
S. Carvalho Fernando, et al., “Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression”, Psychoneuroendocrinology, vol. 37, 2012, pp. 1659-1668.
Carvalho Fernando, S., Beblo, T., Schlosser, N., Terfehr, K., Otte, C., Löwe, B., Wolf, O.T., Spitzer, C., Driessen, M., Wingenfeld, K.: Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. Psychoneuroendocrinology. 37, 1659-1668 (2012).
Carvalho Fernando, Silvia, Beblo, Thomas, Schlosser, Nicole, Terfehr, Kirsten, Otte, Christian, Löwe, Bernd, Wolf, Oliver Tobias, Spitzer, Carsten, Driessen, Martin, and Wingenfeld, Katja. “Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression”. Psychoneuroendocrinology 37.10 (2012): 1659-1668.

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