Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder

Labudda K, Kreisel S, Beblo T, Mertens M, Kurlandchikov O, Bien CG, Driessen M, Woermann FG (2013)
PLoS ONE 8(12): e83677.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Labudda, Kirsten; Kreisel, Stefan; Beblo, Thomas; Mertens, Markus; Kurlandchikov, Oleg; Bien, Christian G.; Driessen, MartinUniBi ; Woermann, Friedrich G.
Abstract / Bemerkung
Results of MRI volumetry in Borderline Personality Disorder (BPD) are inconsistent. Some, but not all, studies reported decreased hippocampus, amygdala, and/or prefrontal volumes. In the current study, we used rater-independent voxel-based morphometry (VBM) in 33 female BPD patients and 33 healthy women. We measured gray matter (GM) volumes of the whole brain and of three volumes of interest (VOI), i.e., the hippocampus/parahippocampal gyrus, the amygdala and the anterior cingulate gyrus (ACC). Analyses were conducted using lifetime diagnoses of posttraumatic stress disorder (PTSD) and major depression (MD) as covariates. We used adversive childhood experiences and the numbers of BPD criteria (as an indicator of disorder severity) to investigate associations with GM volumes. We did not find volume differences between BPD patients and healthy subject, neither of the whole brain nor of the three VOIs, independent of presence or absence of comorbid PTSD and MD. We also did not find a relationship between childhood maltreatment and the patients’ brain volumes. However, within the patient group, the number of BPD criteria fulfilled was inversely correlated with left hippocampal/parahippocampal volume (x=-32, y=-23, z=-18, k=496, t=5.08, p=.007). Consequently, mesiotemporal GM volumes do not seem to differentiate patients from healthy subjects, but might be associated with symptom severity within the BPD group.
Erscheinungsjahr
2013
Zeitschriftentitel
PLoS ONE
Band
8
Ausgabe
12
Art.-Nr.
e83677
eISSN
1932-6203
Page URI
https://pub.uni-bielefeld.de/record/2963362

Zitieren

Labudda K, Kreisel S, Beblo T, et al. Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder. PLoS ONE. 2013;8(12): e83677.
Labudda, K., Kreisel, S., Beblo, T., Mertens, M., Kurlandchikov, O., Bien, C. G., Driessen, M., et al. (2013). Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder. PLoS ONE, 8(12), e83677. https://doi.org/10.1371/journal.pone.0083677
Labudda, K., Kreisel, S., Beblo, T., Mertens, M., Kurlandchikov, O., Bien, C. G., Driessen, M., and Woermann, F. G. (2013). Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder. PLoS ONE 8:e83677.
Labudda, K., et al., 2013. Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder. PLoS ONE, 8(12): e83677.
K. Labudda, et al., “Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder”, PLoS ONE, vol. 8, 2013, : e83677.
Labudda, K., Kreisel, S., Beblo, T., Mertens, M., Kurlandchikov, O., Bien, C.G., Driessen, M., Woermann, F.G.: Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder. PLoS ONE. 8, : e83677 (2013).
Labudda, Kirsten, Kreisel, Stefan, Beblo, Thomas, Mertens, Markus, Kurlandchikov, Oleg, Bien, Christian G., Driessen, Martin, and Woermann, Friedrich G. “Mesiotemporal Volume Loss Associated with Disorder Severity: A VBM Study in Borderline Personality Disorder”. PLoS ONE 8.12 (2013): e83677.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 24367606
PubMed | Europe PMC

Suchen in

Google Scholar