Volume of hippocampal substructures in borderline personality disorder

Kreisel SH, Labudda K, Kurlandchikov O, Beblo T, Mertens M, Thomas C, Rullkötter N, Wingenfeld K, Mensebach C, Woermann FG, Driessen M (2015)
Psychiatry Research: Neuroimaging 231(3): 218-226.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Kreisel, Stefan Henner; Labudda, Kirsten; Kurlandchikov, Oleg; Beblo, Thomas; Mertens, Markus; Thomas, Christine; Rullkötter, Nina; Wingenfeld, Katja; Mensebach, Christoph; Woermann, Friedrich G.; Driessen, MartinUniBi
Abstract / Bemerkung
Borderline personality disorder (BPD) may be associated with smaller hippocampi in comparison to hippocampal size in controls. However, specific pathology in hippocampal substructures (i.e., head, body and tail) has not been sufficiently investigated. To address hippocampal structure in greater detail, we studied 39 psychiatric inpatients and outpatients with a DSM-IV diagnosis of BPD and 39 healthy controls. The hippocampus and its substructures were segmented manually on magnetic resonance imaging scans. The volumes of hippocampal substructures (and total hippocampal volume) did not differ between BPD patients and controls. Exploratory analysis suggests that patients with a lifetime history of posttraumatic stress disorder (PTSD) may have a significantly smaller hippocampus – affecting both the hippocampal head and body – in comparison to BPD patients without comorbid PTSD (difference in total hippocampal volume: −10.5%, 95%CI −2.6 to −18.5, significant). Also, patients fulfilling seven or more DSM-IV BPD criteria showed a hippocampal volume reduction, limited to the hippocampal head (difference in volume of the hippocampal head: −16.5%, 95%CI −6.1 to −26.8, significant). Disease heterogeneity in respect to, for example, symptom severity and psychiatric comorbidities may limit direct comparability between studies; the results presented here may reflect hippocampal volumes in patients who are “less” affected or they may simply be a chance finding. However, there is also the possibility that global effects of BPD on the hippocampus may have previously been overestimated.
Erscheinungsjahr
2015
Zeitschriftentitel
Psychiatry Research: Neuroimaging
Band
231
Ausgabe
3
Seite(n)
218-226
ISSN
09254927
Page URI
https://pub.uni-bielefeld.de/record/2963352

Zitieren

Kreisel SH, Labudda K, Kurlandchikov O, et al. Volume of hippocampal substructures in borderline personality disorder. Psychiatry Research: Neuroimaging. 2015;231(3):218-226.
Kreisel, S. H., Labudda, K., Kurlandchikov, O., Beblo, T., Mertens, M., Thomas, C., Rullkötter, N., et al. (2015). Volume of hippocampal substructures in borderline personality disorder. Psychiatry Research: Neuroimaging, 231(3), 218-226. https://doi.org/10.1016/j.pscychresns.2014.11.010
Kreisel, S. H., Labudda, K., Kurlandchikov, O., Beblo, T., Mertens, M., Thomas, C., Rullkötter, N., Wingenfeld, K., Mensebach, C., Woermann, F. G., et al. (2015). Volume of hippocampal substructures in borderline personality disorder. Psychiatry Research: Neuroimaging 231, 218-226.
Kreisel, S.H., et al., 2015. Volume of hippocampal substructures in borderline personality disorder. Psychiatry Research: Neuroimaging, 231(3), p 218-226.
S.H. Kreisel, et al., “Volume of hippocampal substructures in borderline personality disorder”, Psychiatry Research: Neuroimaging, vol. 231, 2015, pp. 218-226.
Kreisel, S.H., Labudda, K., Kurlandchikov, O., Beblo, T., Mertens, M., Thomas, C., Rullkötter, N., Wingenfeld, K., Mensebach, C., Woermann, F.G., Driessen, M.: Volume of hippocampal substructures in borderline personality disorder. Psychiatry Research: Neuroimaging. 231, 218-226 (2015).
Kreisel, Stefan Henner, Labudda, Kirsten, Kurlandchikov, Oleg, Beblo, Thomas, Mertens, Markus, Thomas, Christine, Rullkötter, Nina, Wingenfeld, Katja, Mensebach, Christoph, Woermann, Friedrich G., and Driessen, Martin. “Volume of hippocampal substructures in borderline personality disorder”. Psychiatry Research: Neuroimaging 231.3 (2015): 218-226.

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