Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity

Chouna HSD, Dize D, Kagho DUK, Bankeu JJK, Fongang YSF, Tali MBT, Ponou BK, Bitchagno GTM, Awantu AF, Tapondjou LA, Lenta BN, et al. (2022)
Parasitology Research.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Chouna, Hardo Suzy Donfack; Dize, Darline; Kagho, Donald Ulrich Kenou; Bankeu, Jean Jules Kezetas; Fongang, Yannick Stephane Fotsing; Tali, Mariscal Brice Tchatat; Ponou, Beaudelaire Kemvoufo; Bitchagno, Gabin Thierry Mbahbou; Awantu, Angelbert Fusi; Tapondjou, Leon Azefack; Lenta, Bruno Ndjakou; Fekam, Fabrice Boyom
Alle
Abstract / Bemerkung
Ripe figs, barks, and wood of Ficus vallis-choudae are used in traditional medicine against several conditions including nausea and malaria. However, its use is still to be scientifically documented and validated. Hence, the aim of the present work was to evaluate the antiplasmodial activity of the dichloromethane-methanol (DCM-MeOH (1:1)) crude extract, their hexane, dichloromethane, ethyl acetate, and methanoli fractions, as well as the isolated chemical constituents. The chemical study of the DCM-MeOH (1:1) crude extract of F. vallis-choudae figs led to the isolation of fifteen (15) known compounds identified based on their spectroscopic data [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), mass spectrometry] and by comparison of these data with those reported in the literature. Some of the isolated compounds were assessed in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-sensitive 3D7 (Pf3D7) and multidrug-resistant Dd2 strains. The dichloromethane fraction exhibited very good antiplasmodial activity against both strains with IC50 values of 13.86mug/mL and 8.18mug/mL, respectively. Among the tested compounds, wighteone (2) was the most active against P. falciparum 3D7 (IC50=24.6±1.5muM) and Dd2 (IC50=11.9±2.4muM) strains. The obtained results could justify the traditional uses of F. vallis-choudae against malaria. Wighteone appears to be the most active ingredient. However, further consideration of this compound as starting point for antimalarial drug discovery will depend upon its selectivity of action towards Plasmodium parasites. HIGHLIGHTS: 15 (fifteen) compounds were isolated from the dichloromethane-methanol extract of Ficus vallis-choudae. Their structures were determined on the basis of their spectroscopic data. The dichloromethane fraction showed promising activities on the Pf3D7 and PfDd2 strains with IC50 values of 13.86 and 8.18g/mL, respectively. Wighteone was the most active compound against PfDd2 (IC50=11.9±2.4muM). © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Erscheinungsjahr
2022
Zeitschriftentitel
Parasitology Research
eISSN
1432-1955
Page URI
https://pub.uni-bielefeld.de/record/2963195

Zitieren

Chouna HSD, Dize D, Kagho DUK, et al. Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity. Parasitology Research. 2022.
Chouna, H. S. D., Dize, D., Kagho, D. U. K., Bankeu, J. J. K., Fongang, Y. S. F., Tali, M. B. T., Ponou, B. K., et al. (2022). Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity. Parasitology Research. https://doi.org/10.1007/s00436-022-07540-5
Chouna, H. S. D., Dize, D., Kagho, D. U. K., Bankeu, J. J. K., Fongang, Y. S. F., Tali, M. B. T., Ponou, B. K., Bitchagno, G. T. M., Awantu, A. F., Tapondjou, L. A., et al. (2022). Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity. Parasitology Research.
Chouna, H.S.D., et al., 2022. Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity. Parasitology Research.
H.S.D. Chouna, et al., “Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity”, Parasitology Research, 2022.
Chouna, H.S.D., Dize, D., Kagho, D.U.K., Bankeu, J.J.K., Fongang, Y.S.F., Tali, M.B.T., Ponou, B.K., Bitchagno, G.T.M., Awantu, A.F., Tapondjou, L.A., Lenta, B.N., Fekam, F.B., Sewald, N., Ngouela, S.A.: Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity. Parasitology Research. (2022).
Chouna, Hardo Suzy Donfack, Dize, Darline, Kagho, Donald Ulrich Kenou, Bankeu, Jean Jules Kezetas, Fongang, Yannick Stephane Fotsing, Tali, Mariscal Brice Tchatat, Ponou, Beaudelaire Kemvoufo, Bitchagno, Gabin Thierry Mbahbou, Awantu, Angelbert Fusi, Tapondjou, Leon Azefack, Lenta, Bruno Ndjakou, Fekam, Fabrice Boyom, Sewald, Norbert, and Ngouela, Silvere Augustin. “Constituents from ripe figs of Ficus vallis-choudae Delile (Moraceae) with antiplasmodial activity”. Parasitology Research (2022).

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