Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors

Schroder G, Reichel M, Spiegel S, Schulze M, Gotz A, Bugaichuk S, Andresen JR, Kullen CM, Andresen R, Schober H-C (2022)
Journal of Orthopaedic Surgery and Research 17(1): 228.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Schroder, Guido; Reichel, Martin; Spiegel, Sven; Schulze, MarkoUniBi ; Gotz, Andreas; Bugaichuk, Semjon; Andresen, Julian Ramin; Kullen, Claus Maximilian; Andresen, Reimer; Schober, Hans-Christof
Abstract / Bemerkung
Background The purpose of the study was to investigate associations between biomechanical resilience (failure load, failure strength) and the microarchitecture of cancellous bone in the vertebrae of human cadavers with low bone density with or without vertebral fractures (VFx). Methods Spines were removed from 13 body donors (approval no. A 2017-0072) and analyzed in regard to bone mineral density (BMD), Hounsfield units (HU), and fracture count (Fx) with the aid of high-resolution CT images. This was followed by the puncture of cancellous bone in the vertebral bodies of C2 to L5 using a Jamshidi (TM) needle. The following parameters were determined on the micro-CT images: bone volume fraction (BVF), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), degree of anisotropy (DA), trabecular number (Tb.N), trabecular pattern factor (Tb.Pf), and connectivity density (Conn.D). The axial load behavior of 104 vertebral specimens (C5, C6, T7, T8, T9, T12, L1, L3) was investigated with a servohydraulic testing machine. Results Individuals with more than 2 fractures had a significantly lower trabecular pattern factor (Tb.Pf), which also proved to be an important factor for a reduced failure load in the regression analysis with differences between the parts of the spine. The failure load (FL) and endplate sizes of normal vertebrae increased with progression in the craniocaudal direction, while the HU was reduced. Failure strength (FS) was significantly greater in the cervical spine than in the thoracic or lumbar spine (p < 0.001), independent of sex. BVF, Tb.Th, Tb.N, and Conn.D were significantly higher in the cervical spine than in the other spinal segments. In contrast, Tb.Sp and Tb.Pf were lowest in the cervical spine. BVF was correlated with FL (r = 0.600, p = 0.030) and FS (r = 0.763, p = 0.002). Microarchitectural changes were also detectable in the cervical spine at lower densities. Conclusions Due to the unique microarchitecture of the cervical vertebrae, fractures occur much later in this region than they do in the thoracic or lumbar spine. Trial registration Approval no. A 2017-0072.
Stichworte
Osteoporosis; Biomechanics; Computed tomography; Insufficiency fracture; Spine; X-ray microtomography
Erscheinungsjahr
2022
Zeitschriftentitel
Journal of Orthopaedic Surgery and Research
Band
17
Ausgabe
1
Art.-Nr.
228
eISSN
1749-799X
Page URI
https://pub.uni-bielefeld.de/record/2962709

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Schroder G, Reichel M, Spiegel S, et al. Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors. Journal of Orthopaedic Surgery and Research . 2022;17(1): 228.
Schroder, G., Reichel, M., Spiegel, S., Schulze, M., Gotz, A., Bugaichuk, S., Andresen, J. R., et al. (2022). Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors. Journal of Orthopaedic Surgery and Research , 17(1), 228. https://doi.org/10.1186/s13018-022-03105-5
Schroder, G., Reichel, M., Spiegel, S., Schulze, M., Gotz, A., Bugaichuk, S., Andresen, J. R., Kullen, C. M., Andresen, R., and Schober, H. - C. (2022). Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors. Journal of Orthopaedic Surgery and Research 17:228.
Schroder, G., et al., 2022. Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors. Journal of Orthopaedic Surgery and Research , 17(1): 228.
G. Schroder, et al., “Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors”, Journal of Orthopaedic Surgery and Research , vol. 17, 2022, : 228.
Schroder, G., Reichel, M., Spiegel, S., Schulze, M., Gotz, A., Bugaichuk, S., Andresen, J.R., Kullen, C.M., Andresen, R., Schober, H.-C.: Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors. Journal of Orthopaedic Surgery and Research . 17, : 228 (2022).
Schroder, Guido, Reichel, Martin, Spiegel, Sven, Schulze, Marko, Gotz, Andreas, Bugaichuk, Semjon, Andresen, Julian Ramin, Kullen, Claus Maximilian, Andresen, Reimer, and Schober, Hans-Christof. “Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors”. Journal of Orthopaedic Surgery and Research 17.1 (2022): 228.

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