Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, Barth P, Bohle RM, Buttner A, Buttner R, Dettmeyer R, et al. (2022)
Virchows Archiv .

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Jonigk, Danny; Werlein, Christopher; Acker, Till; Aepfelbacher, Martin; Amann, Kerstin U; Baretton, Gustavo; Barth, Peter; Bohle, Rainer M; Buttner, Andreas; Buttner, Reinhard; Dettmeyer, Reinhard; Eichhorn, Philip
Alle
Abstract / Bemerkung
The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autopsy techniques, the applicability of modern analytical methods to understand the pathophysiology of COVID-19, the major pathological organ findings, limitations or current studies, and open questions. This article summarizes published literature and the consented experience of the nationwide network of clinical, neuro-, and forensic pathologists from 27 German autopsy centers with more than 1200 COVID-19 autopsies. The autopsy tissues revealed that SARS-CoV-2 can be found in virtually all human organs and tissues, and the majority of cells. Autopsies have revealed the organ and tissue tropism of SARS-CoV-2, and the morphological features of COVID-19. This is characterized by diffuse alveolar damage, combined with angiocentric disease, which in turn is characterized by endothelial dysfunction, vascular inflammation, (micro-) thrombosis, vasoconstriction, and intussusceptive angiogenesis. These findings explained the increased pulmonary resistance in COVID-19 and supported the recommendations for antithrombotic treatment in COVID-19. In contrast, in extra-respiratory organs, pathological changes are often nonspecific and unclear to which extent these changes are due to direct infection vs. indirect/secondary mechanisms of organ injury, or a combination thereof. Ongoing research using autopsies aims at answering questions on disease mechanisms, e.g., focusing on variants of concern, and future challenges, such as post-COVID conditions. Autopsies are an invaluable tool in medicine and national and international interdisciplinary collaborative autopsy-based research initiatives are essential. © 2022. The Author(s).
Erscheinungsjahr
2022
Zeitschriftentitel
Virchows Archiv
eISSN
1432-2307
Page URI
https://pub.uni-bielefeld.de/record/2962341

Zitieren

Jonigk D, Werlein C, Acker T, et al. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Archiv . 2022.
Jonigk, D., Werlein, C., Acker, T., Aepfelbacher, M., Amann, K. U., Baretton, G., Barth, P., et al. (2022). Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Archiv . https://doi.org/10.1007/s00428-022-03319-2
Jonigk, D., Werlein, C., Acker, T., Aepfelbacher, M., Amann, K. U., Baretton, G., Barth, P., Bohle, R. M., Buttner, A., Buttner, R., et al. (2022). Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Archiv .
Jonigk, D., et al., 2022. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Archiv .
D. Jonigk, et al., “Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?”, Virchows Archiv , 2022.
Jonigk, D., Werlein, C., Acker, T., Aepfelbacher, M., Amann, K.U., Baretton, G., Barth, P., Bohle, R.M., Buttner, A., Buttner, R., Dettmeyer, R., Eichhorn, P., Elezkurtaj, S., Esposito, I., Evert, K., Evert, M., Fend, F., GaSSler, N., Gattenlohner, S., Glatzel, M., Gobel, H., Gradhand, E., Hansen, T., Hartmann, A., Heinemann, A., Heppner, F.L., Hilsenbeck, J., Horst, D., Kamp, J.C., Mall, G., Markl, B., Ondruschka, B., Pablik, J., Pfefferle, S., Quaas, A., Radbruch, H., Rocken, C., Rosenwald, A., Roth, W., Rudelius, M., Schirmacher, P., Slotta-Huspenina, J., Smith, K., Sommer, L., Stock, K., Strobel, P., Strobl, S., Titze, U., Weirich, G., Weis, J., Werner, M., Wickenhauser, C., Wiech, T., Wild, P., Welte, T., von Stillfried, S., Boor, P.: Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Archiv . (2022).
Jonigk, Danny, Werlein, Christopher, Acker, Till, Aepfelbacher, Martin, Amann, Kerstin U, Baretton, Gustavo, Barth, Peter, Bohle, Rainer M, Buttner, Andreas, Buttner, Reinhard, Dettmeyer, Reinhard, Eichhorn, Philip, Elezkurtaj, Sefer, Esposito, Irene, Evert, Katja, Evert, Matthias, Fend, Falko, GaSSler, Nikolaus, Gattenlohner, Stefan, Glatzel, Markus, Gobel, Heike, Gradhand, Elise, Hansen, Torsten, Hartmann, Arndt, Heinemann, Axel, Heppner, Frank L, Hilsenbeck, Julia, Horst, David, Kamp, Jan C, Mall, Gita, Markl, Bruno, Ondruschka, Benjamin, Pablik, Jessica, Pfefferle, Susanne, Quaas, Alexander, Radbruch, Helena, Rocken, Christoph, Rosenwald, Andreas, Roth, Wilfried, Rudelius, Martina, Schirmacher, Peter, Slotta-Huspenina, Julia, Smith, Kevin, Sommer, Linna, Stock, Konrad, Strobel, Philipp, Strobl, Stephanie, Titze, Ulf, Weirich, Gregor, Weis, Joachim, Werner, Martin, Wickenhauser, Claudia, Wiech, Thorsten, Wild, Peter, Welte, Tobias, von Stillfried, Saskia, and Boor, Peter. “Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?”. Virchows Archiv (2022).

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 35364700
PubMed | Europe PMC

Suchen in

Google Scholar