In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease
Murai T, Müller U, Werheid K, Sorger D, Reuter M, Becker T, von Cramon DY, Barthel H (2001)
The Journal of Neuropsychiatry and Clinical Neurosciences 13(2): 222-228.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Murai, Toshiya;
Müller, Ulrich;
Werheid, KatjaUniBi 
;
Sorger, Dietlind;
Reuter, Mike;
Becker, Thomas;
von Cramon, D. Yves;
Barthel, Henryk
;
Sorger, Dietlind;
Reuter, Mike;
Becker, Thomas;
von Cramon, D. Yves;
Barthel, HenrykAbstract / Bemerkung
Parkinson's disease affects various neurotransmitter systems. Using SPECT, the authors measured [(123)I]beta-CIT binding ratios of the caudate, putamen, medial thalamus, and dorsal midbrain over cerebellum in 16 patients with Parkinson's disease, and examined correlations with clinical ratings. Whereas striatal binding ratios (reflecting regional dopamine transporter densities) were associated with motor symptoms, dorsal midbrain binding ratios (reflecting regional serotonin transporter densities) were significantly correlated with the mentation, behavior, and mood subscale of the Unified Parkinson's Disease Rating Scale. These findings indicate that degeneration of the nigrostriatal dopaminergic neurons and a dysfunctional serotonergic raphe system contribute differentially to motor deficits and neuropsychiatric symptoms in Parkinson's disease.
Erscheinungsjahr
2001
Zeitschriftentitel
The Journal of Neuropsychiatry and Clinical Neurosciences
Band
13
Ausgabe
2
Seite(n)
222-228
ISSN
0895-0172
eISSN
1545-7222
Page URI
https://pub.uni-bielefeld.de/record/2962095
Zitieren
Murai T, Müller U, Werheid K, et al. In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences. 2001;13(2):222-228.
Murai, T., Müller, U., Werheid, K., Sorger, D., Reuter, M., Becker, T., von Cramon, D. Y., et al. (2001). In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 13(2), 222-228. https://doi.org/10.1176/jnp.13.2.222
Murai, Toshiya, Müller, Ulrich, Werheid, Katja, Sorger, Dietlind, Reuter, Mike, Becker, Thomas, von Cramon, D. Yves, and Barthel, Henryk. 2001. “In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease”. The Journal of Neuropsychiatry and Clinical Neurosciences 13 (2): 222-228.
Murai, T., Müller, U., Werheid, K., Sorger, D., Reuter, M., Becker, T., von Cramon, D. Y., and Barthel, H. (2001). In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences 13, 222-228.
Murai, T., et al., 2001. In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 13(2), p 222-228.
T. Murai, et al., “In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease”, The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 13, 2001, pp. 222-228.
Murai, T., Müller, U., Werheid, K., Sorger, D., Reuter, M., Becker, T., von Cramon, D.Y., Barthel, H.: In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences. 13, 222-228 (2001).
Murai, Toshiya, Müller, Ulrich, Werheid, Katja, Sorger, Dietlind, Reuter, Mike, Becker, Thomas, von Cramon, D. Yves, and Barthel, Henryk. “In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease”. The Journal of Neuropsychiatry and Clinical Neurosciences 13.2 (2001): 222-228.
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