The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control

Korn S, Milger K, Skowasch D, Timmermann H, Taube C, Idzko M, VoSS HW, Holtdirk A, Hamelmann E, Buhl R (2022)
Respiratory Medicine 195: 106793.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Korn, Stephanie; Milger, Katrin; Skowasch, Dirk; Timmermann, Hartmut; Taube, Christian; Idzko, Marco; VoSS, Hans Werner; Holtdirk, Annette; Hamelmann, EckardUniBi; Buhl, Roland
Abstract / Bemerkung
INTRODUCTION: The German Asthma Net Severe Asthma Registry is collecting long-term data from a large cohort of patients aged ≥6 years with severe asthma. This manuscript presents their baseline characteristics, and identifies relationships with exacerbations and/or poor asthma control.; METHODS: The registry is collecting routine clinical parameters including: demographics and medical history; disease characteristics (Asthma Control Questionnaire [ACQ]-5, forced expiratory volume in 1s [FEV1]); exacerbations; and biomarkers (eosinophils, immunoglobulin E [IgE], fractional exhaled nitric oxide [FeNO]).; RESULTS: These analyses include data from 2011 patients at 72 sites (91.9% adult). Children (6-17 years) were more likely to be male, whereas more adults were female (males: children/adults 62%/41%). Most were receiving inhaled corticosteroid/long-acting beta2-agonist combinations (78%/81%); 38.0% of adults were receiving systemic steroids. Asthma control was suboptimal in both groups: 21.5%/13.3% were controlled; 10.4%/49.1% were symptomatic; 33.1%/37.2% received emergency asthma treatment in the previous year. Median blood eosinophil (400/238cells/muL) and IgE levels (494/186 IU/mL) were higher in children; FeNO was lower (19/35ppb). Patients with ≥2 exacerbations in the previous year had lower FEV1 (absolute and % predicted) and IgE, and higher ACQ-5, FeNO and blood eosinophil levels (all p<0.05). There was a weak, negative correlation between ACQ-5 and FEV1% predicted in adults (p<0.001).; CONCLUSIONS: These analyses characterise the typical German patient with severe asthma, and provide information on their overall care. Their planned long-term follow-up will assess whether asthma control can be optimised, how best to do so, and most importantly how such optimisation can benefit patients. Copyright © 2022. Published by Elsevier Ltd.
Erscheinungsjahr
2022
Zeitschriftentitel
Respiratory Medicine
Band
195
Art.-Nr.
106793
eISSN
1532-3064
Page URI
https://pub.uni-bielefeld.de/record/2961740

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Korn S, Milger K, Skowasch D, et al. The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control. Respiratory Medicine . 2022;195: 106793.
Korn, S., Milger, K., Skowasch, D., Timmermann, H., Taube, C., Idzko, M., VoSS, H. W., et al. (2022). The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control. Respiratory Medicine , 195, 106793. https://doi.org/10.1016/j.rmed.2022.106793
Korn, Stephanie, Milger, Katrin, Skowasch, Dirk, Timmermann, Hartmut, Taube, Christian, Idzko, Marco, VoSS, Hans Werner, Holtdirk, Annette, Hamelmann, Eckard, and Buhl, Roland. 2022. “The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control”. Respiratory Medicine 195: 106793.
Korn, S., Milger, K., Skowasch, D., Timmermann, H., Taube, C., Idzko, M., VoSS, H. W., Holtdirk, A., Hamelmann, E., and Buhl, R. (2022). The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control. Respiratory Medicine 195: 106793.
Korn, S., et al., 2022. The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control. Respiratory Medicine , 195: 106793.
S. Korn, et al., “The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control”, Respiratory Medicine , vol. 195, 2022, : 106793.
Korn, S., Milger, K., Skowasch, D., Timmermann, H., Taube, C., Idzko, M., VoSS, H.W., Holtdirk, A., Hamelmann, E., Buhl, R.: The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control. Respiratory Medicine . 195, : 106793 (2022).
Korn, Stephanie, Milger, Katrin, Skowasch, Dirk, Timmermann, Hartmut, Taube, Christian, Idzko, Marco, VoSS, Hans Werner, Holtdirk, Annette, Hamelmann, Eckard, and Buhl, Roland. “The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control”. Respiratory Medicine 195 (2022): 106793.

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