Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation

Merten M, Greiner J, Niemann T, Grosse Venhaus M, Kronenberg D, Stange R, Wähnert D, Kaltschmidt C, Vordemvenne T, Kaltschmidt B (2022)
Cells 11(5): 823.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Merten, MadlenUniBi; Greiner, JohannesUniBi ; Niemann, Tarek; Grosse Venhaus, Meike; Kronenberg, Daniel; Stange, Richard; Wähnert, DirkUniBi; Kaltschmidt, ChristianUniBi; Vordemvenne, Thomas; Kaltschmidt, BarbaraUniBi
Abstract / Bemerkung
Female sex is increasingly associated with a loss of bone mass during aging and an increased risk of developing nonunion fractures. Hormonal factors and cell-intrinsic mechanisms are suggested to drive these sexual dimorphisms, although underlying molecular mechanisms are still a matter of debate. Here, we observed a decreased capacity of calvarial bone recovery in female rats and a profound sexually dimorphic osteogenic differentiation in human adult neural crest-derived stem cells (NCSCs). Next to an elevated expression of pro-osteogenic regulators, global transcriptomics revealed Lysine Demethylase 5D (KDM5D) to be highly upregulated in differentiating male NCSCs. Loss of function by siRNA or pharmacological inhibition of KDM5D significantly reduced the osteogenic differentiation capacity of male NCSCs. In summary, we demonstrated craniofacial osteogenic differentiation to be sexually dimorphic with the expression of KDM5D as a prerequisite for accelerated male osteogenic differentiation, emphasizing the analysis of sex-specific differences as a crucial parameter for treating bone defects.
Stichworte
adult human stem cells; sexual dimorphisms; osteogenic differentiation; KDM5D; calvarial bone regeneration; transcriptional profiling; KDOAM-25
Erscheinungsjahr
2022
Zeitschriftentitel
Cells
Band
11
Ausgabe
5
Art.-Nr.
823
eISSN
2073-4409
Page URI
https://pub.uni-bielefeld.de/record/2961435

Zitieren

Merten M, Greiner J, Niemann T, et al. Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation. Cells. 2022;11(5): 823.
Merten, M., Greiner, J., Niemann, T., Grosse Venhaus, M., Kronenberg, D., Stange, R., Wähnert, D., et al. (2022). Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation. Cells, 11(5), 823. https://doi.org/10.3390/cells11050823
Merten, Madlen, Greiner, Johannes, Niemann, Tarek, Grosse Venhaus, Meike, Kronenberg, Daniel, Stange, Richard, Wähnert, Dirk, Kaltschmidt, Christian, Vordemvenne, Thomas, and Kaltschmidt, Barbara. 2022. “Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation”. Cells 11 (5): 823.
Merten, M., Greiner, J., Niemann, T., Grosse Venhaus, M., Kronenberg, D., Stange, R., Wähnert, D., Kaltschmidt, C., Vordemvenne, T., and Kaltschmidt, B. (2022). Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation. Cells 11:823.
Merten, M., et al., 2022. Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation. Cells, 11(5): 823.
M. Merten, et al., “Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation”, Cells, vol. 11, 2022, : 823.
Merten, M., Greiner, J., Niemann, T., Grosse Venhaus, M., Kronenberg, D., Stange, R., Wähnert, D., Kaltschmidt, C., Vordemvenne, T., Kaltschmidt, B.: Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation. Cells. 11, : 823 (2022).
Merten, Madlen, Greiner, Johannes, Niemann, Tarek, Grosse Venhaus, Meike, Kronenberg, Daniel, Stange, Richard, Wähnert, Dirk, Kaltschmidt, Christian, Vordemvenne, Thomas, and Kaltschmidt, Barbara. “Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation”. Cells 11.5 (2022): 823.
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2022-02-28T06:53:31Z
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