Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis

Dinh TS, Brueckle M-S, Gonzalez-Gonzalez AI, Fessler J, Marschall U, Schubert-Zsilavesz M, Gerlach FM, Harder S, van den Akker M, Schubert I, Muth C (2022)
Journal of Personalized Medicine 12(1): 69.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 689.20 KB
Autor*in
Dinh, Truc Sophia; Brueckle, Maria-Sophie; Gonzalez-Gonzalez, Ana Isabel; Fessler, Joachim; Marschall, Ursula; Schubert-Zsilavesz, Manfred; Gerlach, Ferdinand M; Harder, Sebastian; van den Akker, Marjan; Schubert, Ingrid; Muth, ChristianeUniBi
Abstract / Bemerkung
Evidence-based clinical guidelines generally consider single conditions, and rarely multimorbidity. We developed an evidence-based guideline for a structured care program to manage polypharmacy in multimorbidity by using a realist synthesis to update the German polypharmacy guideline including the following five methods: formal prioritization in focus groups; systematic guideline review of evidence-based multimorbidity/polypharmacy guidelines; evidence search/synthesis and recommendation development; multidisciplinary consent of recommendations; feasibility test of updated guideline. We identified the need for a better description of the target group, decision support, prioritization of medication, consideration of patient preferences and anticholinergic properties, and of healthcare interfaces. We conducted a systematic guideline review of eight guidelines and extracted and synthesized recommendations using the Ariadne principles. We also included 48 systematic reviews. We formulated and agreed upon 34 recommendations for the revised guideline. During the feasibility test, guideline use enabled 57% of GPs to identify problems, leading to medication changes in 49% and self-assessed improvement in 56% of patients. Although 58% of GPs felt that it was too long, 92% recommended it. Polypharmacy should be systematically reviewed at least annually. Patients, family members, and healthcare professionals should monitor and adjust it using prospective process validation, taking into account patient preferences and agreed treatment goals.

Beteiligte Organisation: The Evita Study Group
Erscheinungsjahr
2022
Zeitschriftentitel
Journal of Personalized Medicine
Band
12
Ausgabe
1
Art.-Nr.
69
eISSN
2075-4426
Page URI
https://pub.uni-bielefeld.de/record/2960866

Zitieren

Dinh TS, Brueckle M-S, Gonzalez-Gonzalez AI, et al. Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis. Journal of Personalized Medicine. 2022;12(1): 69.
Dinh, T. S., Brueckle, M. - S., Gonzalez-Gonzalez, A. I., Fessler, J., Marschall, U., Schubert-Zsilavesz, M., Gerlach, F. M., et al. (2022). Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis. Journal of Personalized Medicine, 12(1), 69. https://doi.org/10.3390/jpm12010069
Dinh, T. S., Brueckle, M. - S., Gonzalez-Gonzalez, A. I., Fessler, J., Marschall, U., Schubert-Zsilavesz, M., Gerlach, F. M., Harder, S., van den Akker, M., Schubert, I., et al. (2022). Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis. Journal of Personalized Medicine 12:69.
Dinh, T.S., et al., 2022. Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis. Journal of Personalized Medicine, 12(1): 69.
T.S. Dinh, et al., “Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis”, Journal of Personalized Medicine, vol. 12, 2022, : 69.
Dinh, T.S., Brueckle, M.-S., Gonzalez-Gonzalez, A.I., Fessler, J., Marschall, U., Schubert-Zsilavesz, M., Gerlach, F.M., Harder, S., van den Akker, M., Schubert, I., Muth, C.: Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis. Journal of Personalized Medicine. 12, : 69 (2022).
Dinh, Truc Sophia, Brueckle, Maria-Sophie, Gonzalez-Gonzalez, Ana Isabel, Fessler, Joachim, Marschall, Ursula, Schubert-Zsilavesz, Manfred, Gerlach, Ferdinand M, Harder, Sebastian, van den Akker, Marjan, Schubert, Ingrid, and Muth, Christiane. “Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis”. Journal of Personalized Medicine 12.1 (2022): 69.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0):
Volltext(e)
Name
Access Level
OA Open Access
Zuletzt Hochgeladen
2022-04-13T14:02:39Z
MD5 Prüfsumme
b0fafa1dbbe28d28fe3bde9525a423d1

Link(s) zu Volltext(en)
Access Level
OA Open Access

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 35055383
PubMed | Europe PMC

Suchen in

Google Scholar