Recent advances in the metabolic pathways and microbial production of coenzyme Q

Pierrel F, Burgardt A, Lee J-H, Pelosi L, Wendisch VF (2022)
World Journal of Microbiology and Biotechnology 38(4): 58.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Pierrel, Fabien; Burgardt, ArthurUniBi; Lee, Jin-Ho; Pelosi, Ludovic; Wendisch, Volker F.UniBi
Abstract / Bemerkung
Coenzyme Q (CoQ) serves as an electron carrier in aerobic respiration and has become an interesting target for biotechnological production due to its antioxidative effect and benefits in supplementation to patients with various diseases. Here, we review discovery of the pathway with a particular focus on its superstructuration and regulation, and we summarize the metabolic engineering strategies for overproduction of CoQ by microorganisms. Studies in model microorganisms elucidated the details of CoQ biosynthesis and revealed the existence of multiprotein complexes composed of several enzymes that catalyze consecutive reactions in the CoQ pathways of Saccharomyces cerevisiae and Escherichia coli. Recent findings indicate that the identity and the total number of proteins involved in CoQ biosynthesis vary between species, which raises interesting questions about the evolution of the pathway and could provide opportunities for easier engineering of CoQ production. For the biotechnological production, so far only microorganisms have been used that naturally synthesize CoQ10 or a related CoQ species. CoQ biosynthesis requires the aromatic precursor 4-hydroxybenzoic acid and the prenyl side chain that defines the CoQ species. Up to now, metabolic engineering strategies concentrated on the overproduction of the prenyl side chain as well as fine-tuning the expression of ubi genes from the ubiquinone modification pathway, resulting in high CoQ yields. With expanding knowledge about CoQ biosynthesis and exploration of new strategies for strain engineering, microbial CoQ production is expected to improve.
Erscheinungsjahr
2022
Zeitschriftentitel
World Journal of Microbiology and Biotechnology
Band
38
Ausgabe
4
Art.-Nr.
58
ISSN
0265-0762
eISSN
1573-0972
Page URI
https://pub.uni-bielefeld.de/record/2960845

Zitieren

Pierrel F, Burgardt A, Lee J-H, Pelosi L, Wendisch VF. Recent advances in the metabolic pathways and microbial production of coenzyme Q . World Journal of Microbiology and Biotechnology. 2022;38(4): 58.
Pierrel, F., Burgardt, A., Lee, J. - H., Pelosi, L., & Wendisch, V. F. (2022). Recent advances in the metabolic pathways and microbial production of coenzyme Q . World Journal of Microbiology and Biotechnology, 38(4), 58. https://doi.org/10.1007/s11274-022-03242-3
Pierrel, F., Burgardt, A., Lee, J. - H., Pelosi, L., and Wendisch, V. F. (2022). Recent advances in the metabolic pathways and microbial production of coenzyme Q . World Journal of Microbiology and Biotechnology 38:58.
Pierrel, F., et al., 2022. Recent advances in the metabolic pathways and microbial production of coenzyme Q . World Journal of Microbiology and Biotechnology, 38(4): 58.
F. Pierrel, et al., “Recent advances in the metabolic pathways and microbial production of coenzyme Q ”, World Journal of Microbiology and Biotechnology, vol. 38, 2022, : 58.
Pierrel, F., Burgardt, A., Lee, J.-H., Pelosi, L., Wendisch, V.F.: Recent advances in the metabolic pathways and microbial production of coenzyme Q . World Journal of Microbiology and Biotechnology. 38, : 58 (2022).
Pierrel, Fabien, Burgardt, Arthur, Lee, Jin-Ho, Pelosi, Ludovic, and Wendisch, Volker F. “Recent advances in the metabolic pathways and microbial production of coenzyme Q ”. World Journal of Microbiology and Biotechnology 38.4 (2022): 58.
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2022-02-18T07:51:30Z
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