Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine

Garba JK, Nguengang RT, Youmbi GT, Menatche JN, Ngansop CAN, Bankeu JJK, Chouna JR, Boyom FF, Sewald N, Lenta BN (2022)
Zeitschrift für Naturforschung B 77(1): 9-15.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Garba, Jean Koffi; Nguengang, Ruland Tchuinkeu; Youmbi, Gwladys Tatiana; Menatche, Joel Njopnu; Ngansop, Cyrille Armel Njanpa; Bankeu, Jean Jules Kezetas; Chouna, Jean Rodolphe; Boyom, Fabrice Fekam; Sewald, NorbertUniBi ; Lenta, Bruno Ndjakou
Abstract / Bemerkung
**Abstract**
The search for antileishmanial plants used in traditional medicine led to the choice of CH2Cl2–MeOH (1:1) crude extract of the fruits and stem bark ofPentadesma butyraceaSabine (Clusiaceae) which displayed good activityin vitroagainstLeishmania donovani1S (MHOM/SD/62/1S) promastigotes during preliminary screening with IC50values 5.96 and 26.43 μg mL−1, respectively. The fractionation of both extracts using flash chromatography yielded active fractions with IC50values ranging from 2.71 to 18.88 μg mL−1. Fourteen compounds (114) were isolated from the obtained fractions using successive column chromatographies and their structures were elucidated based on the analysis of their NMR and MS data. Daphnifolin (1), epicathechin (3), α-mangostin (9) and 9-hydroxycalabaxanthone (14) exhibited potent antileismanial activity againstL. donovani1S (MHOM/SD/62/1S) promastigotes with IC50values of 2.01, 9.09, 3.37, and 6.87 μg mL−1, respectively and good selectivity towards Raw 264.7 macrophage cells (SI > 2.4). Extracts, fractions and some isolates were also assessed in vitro for their antibacterial activity against six bacterial strains [Salmonella typhi(CPC),Enterobacter cloacae(CPC),Pseudomonas aeruginosaHM801,Staphylococcus aureusATCC 43300,Streptococcus pneumoniaeATCC 491619,Escherichia coliATCC 25322] using serial microdilution method. Among the tested samples, the stem bark extract ofP. butyraceaas well as compounds2and8showed good to moderate activity against the aforementioned bacterial strains with MIC ≤ 250 μg mL−1.
Erscheinungsjahr
2022
Zeitschriftentitel
Zeitschrift für Naturforschung B
Band
77
Ausgabe
1
Seite(n)
9-15
ISSN
0932-0776
eISSN
1865-7117
Page URI
https://pub.uni-bielefeld.de/record/2960546

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Garba JK, Nguengang RT, Youmbi GT, et al. Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine. Zeitschrift für Naturforschung B. 2022;77(1):9-15.
Garba, J. K., Nguengang, R. T., Youmbi, G. T., Menatche, J. N., Ngansop, C. A. N., Bankeu, J. J. K., Chouna, J. R., et al. (2022). Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine. Zeitschrift für Naturforschung B, 77(1), 9-15. https://doi.org/10.1515/znb-2021-0077
Garba, Jean Koffi, Nguengang, Ruland Tchuinkeu, Youmbi, Gwladys Tatiana, Menatche, Joel Njopnu, Ngansop, Cyrille Armel Njanpa, Bankeu, Jean Jules Kezetas, Chouna, Jean Rodolphe, Boyom, Fabrice Fekam, Sewald, Norbert, and Lenta, Bruno Ndjakou. 2022. “Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine”. Zeitschrift für Naturforschung B 77 (1): 9-15.
Garba, J. K., Nguengang, R. T., Youmbi, G. T., Menatche, J. N., Ngansop, C. A. N., Bankeu, J. J. K., Chouna, J. R., Boyom, F. F., Sewald, N., and Lenta, B. N. (2022). Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine. Zeitschrift für Naturforschung B 77, 9-15.
Garba, J.K., et al., 2022. Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine. Zeitschrift für Naturforschung B, 77(1), p 9-15.
J.K. Garba, et al., “Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine”, Zeitschrift für Naturforschung B, vol. 77, 2022, pp. 9-15.
Garba, J.K., Nguengang, R.T., Youmbi, G.T., Menatche, J.N., Ngansop, C.A.N., Bankeu, J.J.K., Chouna, J.R., Boyom, F.F., Sewald, N., Lenta, B.N.: Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine. Zeitschrift für Naturforschung B. 77, 9-15 (2022).
Garba, Jean Koffi, Nguengang, Ruland Tchuinkeu, Youmbi, Gwladys Tatiana, Menatche, Joel Njopnu, Ngansop, Cyrille Armel Njanpa, Bankeu, Jean Jules Kezetas, Chouna, Jean Rodolphe, Boyom, Fabrice Fekam, Sewald, Norbert, and Lenta, Bruno Ndjakou. “Antileishmanial, antibacterial and cytotoxicity activity of the extracts, fractions, and compounds from the fruits and stem bark extracts of Sabine”. Zeitschrift für Naturforschung B 77.1 (2022): 9-15.
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