Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis

Bellucci R, Oertelt S, Gallagher M, Li S, Zorn E, Weller E, Porcheray F, Alyea EP, Soiffer RJ, Munshi NC, Gershwin ME, et al. (2006)
Blood 109(5): 2001-2007.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Bellucci, Roberto; Oertelt, SabineUniBi ; Gallagher, Meagan; Li, Sigui; Zorn, Emmanuel; Weller, Edie; Porcheray, Fabrice; Alyea, Edwin P.; Soiffer, Robert J.; Munshi, Nikhil C.; Gershwin, M. Eric; Ritz, Jerome
Alle
Abstract / Bemerkung
A unique characteristic of the autoimmune liver disease primary biliary cirrhosis (PBC) is the presence of high-titer and extremely specific autoantibodies to the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Autoantibodies to PDC-E2 antigen have only been detected in patients with disease or in those who subsequently develop PBC. One exception has been a subgroup of patients with multiple myeloma (MM) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) and received donor lymphocyte infusions (DLIs) after transplantation. These patients developed high-titer antibodies to a variety of myeloma-associated antigens, including PDC-E2, coincident with rejection of myeloma cells in vivo. To examine the specificity of autoantibodies to PDC in these patients, we screened sera from patients with MM, chronic leukemias, monoclonal gammopathy of unknown significance (MGUS), PBC, and healthy donors. Three of 11 patients with MM (27%) and 2 of 6 patients with chronic leukemias (33%) developed anti–PDC-E2 antibodies in association with DLI response; 2 of 12 (17%) patients in the MGUS pretreatment control population also had detectable anti-PDC responses. Interestingly, the epitope specificity of these PDC-E2 autoantibodies was distinctive, suggesting that the mechanisms leading to loss of tolerance in the transplantation patients are distinct from PBC.
Erscheinungsjahr
2006
Zeitschriftentitel
Blood
Band
109
Ausgabe
5
Seite(n)
2001-2007
ISSN
0006-4971
eISSN
1528-0020
Page URI
https://pub.uni-bielefeld.de/record/2960021

Zitieren

Bellucci R, Oertelt S, Gallagher M, et al. Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood. 2006;109(5):2001-2007.
Bellucci, R., Oertelt, S., Gallagher, M., Li, S., Zorn, E., Weller, E., Porcheray, F., et al. (2006). Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood, 109(5), 2001-2007. https://doi.org/10.1182/blood-2006-06-030304
Bellucci, R., Oertelt, S., Gallagher, M., Li, S., Zorn, E., Weller, E., Porcheray, F., Alyea, E. P., Soiffer, R. J., Munshi, N. C., et al. (2006). Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood 109, 2001-2007.
Bellucci, R., et al., 2006. Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood, 109(5), p 2001-2007.
R. Bellucci, et al., “Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis”, Blood, vol. 109, 2006, pp. 2001-2007.
Bellucci, R., Oertelt, S., Gallagher, M., Li, S., Zorn, E., Weller, E., Porcheray, F., Alyea, E.P., Soiffer, R.J., Munshi, N.C., Gershwin, M.E., Ritz, J.: Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood. 109, 2001-2007 (2006).
Bellucci, Roberto, Oertelt, Sabine, Gallagher, Meagan, Li, Sigui, Zorn, Emmanuel, Weller, Edie, Porcheray, Fabrice, Alyea, Edwin P., Soiffer, Robert J., Munshi, Nikhil C., Gershwin, M. Eric, and Ritz, Jerome. “Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis”. Blood 109.5 (2006): 2001-2007.

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