Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure
Regitz-Zagrosek V, Oertelt-Prigione S, Seeland U, Hetzer R (2010)
Circulation Journal 74(7): 1265-1273.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Regitz-Zagrosek, Vera;
Oertelt-Prigione, SabineUniBi ;
Seeland, Ute;
Hetzer, Roland
Abstract / Bemerkung
Heart failure (HF) is a leading cause of cardiovascular mortality and morbidity in the Western world. It affects men at younger age than women. Women have more frequently diastolic HF, associated with the major risk factors of diabetes and hypertension and men have more frequently systolic HF because of coronary artery disease. Under stress, male hearts develop more easily pathological hypertrophy with dilatation and poor systolic function than female hearts. Women with aortic stenosis have more concentric hypertrophy with better systolic function, less upregulation of extracellular matrix genes and better reversibility after unloading. Stressed female hearts maintain energy metabolism better than male hearts and are better protected against calcium overload. Estrogens and androgens and their receptors are present in the myocardium and lead to coordinated regulation of functionally relevant pathways. Atrial fibrillation (AF) is a more ominous sign in women than in men. Men with end-stage cardiomyopathy more frequently have auto-antibodies than women. Women receive less guideline-based diagnostics and therapy. Expensive and invasive therapies such as advanced pacemakers and transplantation are underused in women. Drug studies point at sex differences in efficacy. Despite worse diagnostics and therapy, prognosis is better in women than in men.
Erscheinungsjahr
2010
Zeitschriftentitel
Circulation Journal
Band
74
Ausgabe
7
Seite(n)
1265-1273
ISSN
1346-9843
eISSN
1347-4820
Page URI
https://pub.uni-bielefeld.de/record/2960012
Zitieren
Regitz-Zagrosek V, Oertelt-Prigione S, Seeland U, Hetzer R. Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure. Circulation Journal. 2010;74(7):1265-1273.
Regitz-Zagrosek, V., Oertelt-Prigione, S., Seeland, U., & Hetzer, R. (2010). Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure. Circulation Journal, 74(7), 1265-1273. https://doi.org/10.1253/circj.CJ-10-0196
Regitz-Zagrosek, Vera, Oertelt-Prigione, Sabine, Seeland, Ute, and Hetzer, Roland. 2010. “Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure”. Circulation Journal 74 (7): 1265-1273.
Regitz-Zagrosek, V., Oertelt-Prigione, S., Seeland, U., and Hetzer, R. (2010). Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure. Circulation Journal 74, 1265-1273.
Regitz-Zagrosek, V., et al., 2010. Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure. Circulation Journal, 74(7), p 1265-1273.
V. Regitz-Zagrosek, et al., “Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure”, Circulation Journal, vol. 74, 2010, pp. 1265-1273.
Regitz-Zagrosek, V., Oertelt-Prigione, S., Seeland, U., Hetzer, R.: Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure. Circulation Journal. 74, 1265-1273 (2010).
Regitz-Zagrosek, Vera, Oertelt-Prigione, Sabine, Seeland, Ute, and Hetzer, Roland. “Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure”. Circulation Journal 74.7 (2010): 1265-1273.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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Daten bereitgestellt von Europe PubMed Central.
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Daten bereitgestellt von Europe PubMed Central.
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