Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate

Titze U, Hansen T, Brochhausen C, Titze B, Schulz B, Gunnemann A, Rocco B, Sievert K-D (2021)
Cancers 13(22): 5685.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Titze, UlfUniBi; Hansen, TorstenUniBi; Brochhausen, Christoph; Titze, Barbara; Schulz, Birte; Gunnemann, Alfons; Rocco, Bernardo; Sievert, Karl-DietrichUniBi
Abstract / Bemerkung
Background: Fluorescence confocal microscopy (FCM) is a novel micro-imaging technique providing optical sections of examined tissue. The method has been well established for the diagnosis of tumors in dermatological specimens. Methods: We compare intraoperative diagnoses of the real-time application of FCM in pre-therapeutic prostate biopsies (35 patients, total number of biopsy specimens: n = 438) with the findings of conventional histology. Results: Prostate carcinoma was reliably diagnosed in all patients. Depending on scan quality and experience of the examiner, smaller lesions of well differentiated carcinoma (ISUP1) could not be consistently differentiated from reactive changes. Furthermore, in some cases there was difficulty to distinguish ISUP grade 2 from ISUP grade 1 tumors. ISUP grades 3–5 were reliably detected in FCM. Conclusions: Despite some limitations, FCM seems to be an effective tool for the timely assessment of prostate biopsies enabling reliable diagnosis of prostate cancer in patients requiring therapy.
Erscheinungsjahr
2021
Zeitschriftentitel
Cancers
Band
13
Ausgabe
22
Art.-Nr.
5685
eISSN
2072-6694
Page URI
https://pub.uni-bielefeld.de/record/2959936

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Titze U, Hansen T, Brochhausen C, et al. Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate. Cancers. 2021;13(22): 5685.
Titze, U., Hansen, T., Brochhausen, C., Titze, B., Schulz, B., Gunnemann, A., Rocco, B., et al. (2021). Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate. Cancers, 13(22), 5685. https://doi.org/10.3390/cancers13225685
Titze, Ulf, Hansen, Torsten, Brochhausen, Christoph, Titze, Barbara, Schulz, Birte, Gunnemann, Alfons, Rocco, Bernardo, and Sievert, Karl-Dietrich. 2021. “Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate”. Cancers 13 (22): 5685.
Titze, U., Hansen, T., Brochhausen, C., Titze, B., Schulz, B., Gunnemann, A., Rocco, B., and Sievert, K. - D. (2021). Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate. Cancers 13:5685.
Titze, U., et al., 2021. Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate. Cancers, 13(22): 5685.
U. Titze, et al., “Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate”, Cancers, vol. 13, 2021, : 5685.
Titze, U., Hansen, T., Brochhausen, C., Titze, B., Schulz, B., Gunnemann, A., Rocco, B., Sievert, K.-D.: Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate. Cancers. 13, : 5685 (2021).
Titze, Ulf, Hansen, Torsten, Brochhausen, Christoph, Titze, Barbara, Schulz, Birte, Gunnemann, Alfons, Rocco, Bernardo, and Sievert, Karl-Dietrich. “Diagnostic Performance of Ex Vivo Fluorescence Confocal Microscopy in the Assessment of Diagnostic Biopsies of the Prostate”. Cancers 13.22 (2021): 5685.
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