Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae)

Waleguele CC, Tchuente Tchuenmogne MA, Fotsing Fongang YS, Ngatchou J, Kezetas Bankeu JJ, Ngouela AS, Tsamo E, Sewald N, Krause RWM, Lenta BN (Accepted)
Zeitschrift für Naturforschung C.

Zeitschriftenaufsatz | Angenommen | Englisch
 
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Autor*in
Waleguele, Christine Claire; Tchuente Tchuenmogne, Marthe Aimée; Fotsing Fongang, Yannick Stéphane; Ngatchou, Jules; Kezetas Bankeu, Jean Jules; Ngouela, Augustin Silvère; Tsamo, Etienne; Sewald, NorbertUniBi ; Krause, Rui Werner Maçedo; Lenta, Bruno Ndjakou
Abstract / Bemerkung
**Abstract**
The antiplasmodium assay-guided investigation of the roots, stem bark, and leaves ofPersea americanaMill. led to the isolation of a new fatty alcohol, perseatriol (1), along with six known compounds (2–7). Their structures were elucidated based on the analysis of their NMR and MS data. All crude extracts and fractions exhibited good antiplasmodial activity onPlasmoduim falciparum3D7 with IC50values ranging from 0.76 to 10.5 μg/mL; they also displayed cytotoxicity against HeLa cells with low selectivity indexes (SIs). A preliminaryPlasmodiumlactate dehydrogenase (pLDH) assay was also performed on the isolated compounds. 9,9′-Di-O-feruloyl-5,5′-dimethoxysecoisolariciresinol (4) turned out to be non-toxic and displayed the best activities onP. falciparumwith an IC50value of 0.05 μM, comparable to the reference drug chloroquine with an IC50value of 0.03 μM. Furthermore, besides compound4, this work reports the first isolation of lutein (2) and scopoletin (3) fromP. americana. The crude extracts of roots, stem bark, and leaves ofP. americana, their fractions and compounds completely suppressed the growth ofP. falciparum. The observed activity supports the use ofP. americanain folk medicine for the treatment of malaria.
Erscheinungsjahr
2021
Zeitschriftentitel
Zeitschrift für Naturforschung C
ISSN
0939-5075
eISSN
1865-7125
Page URI
https://pub.uni-bielefeld.de/record/2959393

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Waleguele CC, Tchuente Tchuenmogne MA, Fotsing Fongang YS, et al. Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae). Zeitschrift für Naturforschung C. Accepted.
Waleguele, C. C., Tchuente Tchuenmogne, M. A., Fotsing Fongang, Y. S., Ngatchou, J., Kezetas Bankeu, J. J., Ngouela, A. S., Tsamo, E., et al. (Accepted). Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae). Zeitschrift für Naturforschung C. https://doi.org/10.1515/znc-2021-0182
Waleguele, Christine Claire, Tchuente Tchuenmogne, Marthe Aimée, Fotsing Fongang, Yannick Stéphane, Ngatchou, Jules, Kezetas Bankeu, Jean Jules, Ngouela, Augustin Silvère, Tsamo, Etienne, Sewald, Norbert, Krause, Rui Werner Maçedo, and Lenta, Bruno Ndjakou. Accepted. “Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae)”. Zeitschrift für Naturforschung C.
Waleguele, C. C., Tchuente Tchuenmogne, M. A., Fotsing Fongang, Y. S., Ngatchou, J., Kezetas Bankeu, J. J., Ngouela, A. S., Tsamo, E., Sewald, N., Krause, R. W. M., and Lenta, B. N. (Accepted). Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae). Zeitschrift für Naturforschung C.
Waleguele, C.C., et al., Accepted. Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae). Zeitschrift für Naturforschung C.
C.C. Waleguele, et al., “Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae)”, Zeitschrift für Naturforschung C, Accepted.
Waleguele, C.C., Tchuente Tchuenmogne, M.A., Fotsing Fongang, Y.S., Ngatchou, J., Kezetas Bankeu, J.J., Ngouela, A.S., Tsamo, E., Sewald, N., Krause, R.W.M., Lenta, B.N.: Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae). Zeitschrift für Naturforschung C. (Accepted).
Waleguele, Christine Claire, Tchuente Tchuenmogne, Marthe Aimée, Fotsing Fongang, Yannick Stéphane, Ngatchou, Jules, Kezetas Bankeu, Jean Jules, Ngouela, Augustin Silvère, Tsamo, Etienne, Sewald, Norbert, Krause, Rui Werner Maçedo, and Lenta, Bruno Ndjakou. “Bioguided isolation of antiplasmodial secondary metabolites from Mill. (Lauraceae)”. Zeitschrift für Naturforschung C (Accepted).
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