Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves

Elsayed HE, Kamel RA, Ibrahim RR, Abdel-Razek AS, Shaaban MA, Frese M, Sewald N, Ebrahim HY, Moharram FA (2021)
Frontiers in Chemistry 9: 760083.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Elsayed, Heba E.; Kamel, Reem A.; Ibrahim, Reham R.; Abdel-Razek, Ahmed S.; Shaaban, Mohamed A.; Frese, MarcelUniBi ; Sewald, NorbertUniBi ; Ebrahim, Hassan Y.; Moharram, Fatma A.
Abstract / Bemerkung
Endophytes are prolific producers of privileged secondary metabolites with diverse therapeutic potential, although their anticancer and antimicrobial potential still have a room for further investigation. Herein, seven known secondary metabolites namely, arugosin C (1), ergosterol (2), iso-emericellin (3), sterigmatocystin (4), dihydrosterigmatocystin (5), versicolorin B (6), and diorcinol (7) were isolated from the rice culture ofAspergillus sp.retrieved fromTecoma stans(L.) Juss. ex Kunth leaves. Their anticancer and antimicrobial activities were evaluated in MTT and agar well diffusion assays, respectively. The cytotoxicity results showed that metabolite3displayed the best viability inhibition on the MCF-7 breast cancer cells with IC50= 225.21 µM, while5on the HepG2 hepatocellular carcinoma cells with IC50= 161.81 µM.5demonstrated a 60% apoptotic mode of cell death which is virtually correlated to its high docking affinity to Hsp90 ATP binding cleft (binding score −8.4 Kcal/mol). On the other side, metabolites4and5displayed promising antimicrobial activity especially onPseudomonas aeruginosawith MIC = 125 μg/ml. The observed effect may be likely related to their excellentin silicoinhibition of the bacterial DNA-gyrase kinase domain (binding score −10.28 Kcal/mol). To the best of our knowledge, this study is the first to report the promising cytotoxic and antibacterial activities of metabolites 3, 4, and 5 which needs further investigation and renovation to therapeutic leads.
Erscheinungsjahr
2021
Zeitschriftentitel
Frontiers in Chemistry
Band
9
Art.-Nr.
760083
eISSN
2296-2646
Page URI
https://pub.uni-bielefeld.de/record/2958876

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Elsayed HE, Kamel RA, Ibrahim RR, et al. Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves. Frontiers in Chemistry. 2021;9: 760083.
Elsayed, H. E., Kamel, R. A., Ibrahim, R. R., Abdel-Razek, A. S., Shaaban, M. A., Frese, M., Sewald, N., et al. (2021). Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves. Frontiers in Chemistry, 9, 760083. https://doi.org/10.3389/fchem.2021.760083
Elsayed, H. E., Kamel, R. A., Ibrahim, R. R., Abdel-Razek, A. S., Shaaban, M. A., Frese, M., Sewald, N., Ebrahim, H. Y., and Moharram, F. A. (2021). Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves. Frontiers in Chemistry 9:760083.
Elsayed, H.E., et al., 2021. Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves. Frontiers in Chemistry, 9: 760083.
H.E. Elsayed, et al., “Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves”, Frontiers in Chemistry, vol. 9, 2021, : 760083.
Elsayed, H.E., Kamel, R.A., Ibrahim, R.R., Abdel-Razek, A.S., Shaaban, M.A., Frese, M., Sewald, N., Ebrahim, H.Y., Moharram, F.A.: Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves. Frontiers in Chemistry. 9, : 760083 (2021).
Elsayed, Heba E., Kamel, Reem A., Ibrahim, Reham R., Abdel-Razek, Ahmed S., Shaaban, Mohamed A., Frese, Marcel, Sewald, Norbert, Ebrahim, Hassan Y., and Moharram, Fatma A. “Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves”. Frontiers in Chemistry 9 (2021): 760083.
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2021-11-08T14:07:47Z
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