Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities

Seumo, Amanda Seumo; Nanfack, Arno Rusel D; Ndontsa, Blanche Laure; Bitchagno, Gabin Thierry M; Mbouangouere, Roukayatou; Lenta, Bruno N; Sewald, Norbert; Tane, Pierre; Tene, Mathieu; Ngouela, Silvere Augustin

Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities

Seumo AS, Nanfack ARD, Ndontsa BL, Bitchagno GTM, Mbouangouere R, Lenta BN, Sewald N, Tane P, Tene M, Ngouela SA (2021)
Natural Product Research .

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch

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DOI

https://doi.org/10.1080/14786419.2021.1994565

Autor*in

Seumo, Amanda Seumo; Nanfack, Arno Rusel D; Ndontsa, Blanche Laure; Bitchagno, Gabin Thierry M; Mbouangouere, Roukayatou; Lenta, Bruno N; Sewald, Norbert^UniBi ; Tane, Pierre; Tene, Mathieu; Ngouela, Silvere Augustin

Einrichtung

Fakultät für Chemie > Organische Chemie III

Abstract / Bemerkung

A phytochemical study of the methanol extract of the fruit of Maesa lanceolata resulted in the isolation of a new alkenylbenzoquinone (1), alongside the known compounds (Z)-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone (2), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone (3), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone (4), (2S,3S,4R,2'R,9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol (5), monopalmitin (glyceryl palmitate) (6), lupeol (7), and 3-O-(beta-D-glucopyranoside)-beta-sitosterol (8). The structures of the compounds were established by the means of spectroscopic (1D- and 2D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities. Compound 2 showed moderate activity against Staphylococcus warneri (DSMZ 20036), while the other compounds were inactive. The two quinones 1 and 2 were significantly cytotoxic, with IC50 values of 0.005M and 12.5M respectively, and were weakly active towards DPPH radical (IC50 >250g/mL).

Erscheinungsjahr

2021

Zeitschriftentitel

Natural Product Research

eISSN

1478-6427

Page URI

https://pub.uni-bielefeld.de/record/2958722

Zitieren

Seumo AS, Nanfack ARD, Ndontsa BL, et al. Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research . 2021.

Seumo, A. S., Nanfack, A. R. D., Ndontsa, B. L., Bitchagno, G. T. M., Mbouangouere, R., Lenta, B. N., Sewald, N., et al. (2021). Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research . https://doi.org/10.1080/14786419.2021.1994565

Seumo, Amanda Seumo, Nanfack, Arno Rusel D, Ndontsa, Blanche Laure, Bitchagno, Gabin Thierry M, Mbouangouere, Roukayatou, Lenta, Bruno N, Sewald, Norbert, Tane, Pierre, Tene, Mathieu, and Ngouela, Silvere Augustin. 2021. “Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities”. Natural Product Research .

Seumo, A. S., Nanfack, A. R. D., Ndontsa, B. L., Bitchagno, G. T. M., Mbouangouere, R., Lenta, B. N., Sewald, N., Tane, P., Tene, M., and Ngouela, S. A. (2021). Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research .

Seumo, A.S., et al., 2021. Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research .

A.S. Seumo, et al., “Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities”, Natural Product Research , 2021.

Seumo, A.S., Nanfack, A.R.D., Ndontsa, B.L., Bitchagno, G.T.M., Mbouangouere, R., Lenta, B.N., Sewald, N., Tane, P., Tene, M., Ngouela, S.A.: Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research . (2021).

Seumo, Amanda Seumo, Nanfack, Arno Rusel D, Ndontsa, Blanche Laure, Bitchagno, Gabin Thierry M, Mbouangouere, Roukayatou, Lenta, Bruno N, Sewald, Norbert, Tane, Pierre, Tene, Mathieu, and Ngouela, Silvere Augustin. “Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities”. Natural Product Research (2021).

Daten bereitgestellt von European Bioinformatics Institute (EBI)