Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities
Seumo AS, Nanfack ARD, Ndontsa BL, Bitchagno GTM, Mbouangouere R, Lenta BN, Sewald N, Tane P, Tene M, Ngouela SA (2021)
Natural Product Research .
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Autor*in
Seumo, Amanda Seumo;
Nanfack, Arno Rusel D;
Ndontsa, Blanche Laure;
Bitchagno, Gabin Thierry M;
Mbouangouere, Roukayatou;
Lenta, Bruno N;
Sewald, NorbertUniBi 
;
Tane, Pierre;
Tene, Mathieu;
Ngouela, Silvere Augustin
;
Tane, Pierre;
Tene, Mathieu;
Ngouela, Silvere AugustinEinrichtung
Abstract / Bemerkung
A phytochemical study of the methanol extract of the fruit of Maesa lanceolata resulted in the isolation of a new alkenylbenzoquinone (1), alongside the known compounds (Z)-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone (2), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone (3), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone (4), (2S,3S,4R,2'R,9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol (5), monopalmitin (glyceryl palmitate) (6), lupeol (7), and 3-O-(beta-D-glucopyranoside)-beta-sitosterol (8). The structures of the compounds were established by the means of spectroscopic (1D- and 2D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities. Compound 2 showed moderate activity against Staphylococcus warneri (DSMZ 20036), while the other compounds were inactive. The two quinones 1 and 2 were significantly cytotoxic, with IC50 values of 0.005M and 12.5M respectively, and were weakly active towards DPPH radical (IC50 >250g/mL).
Erscheinungsjahr
2021
Zeitschriftentitel
Natural Product Research
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2958722
Zitieren
Seumo AS, Nanfack ARD, Ndontsa BL, et al. Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research . 2021.
Seumo, A. S., Nanfack, A. R. D., Ndontsa, B. L., Bitchagno, G. T. M., Mbouangouere, R., Lenta, B. N., Sewald, N., et al. (2021). Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research . https://doi.org/10.1080/14786419.2021.1994565
Seumo, Amanda Seumo, Nanfack, Arno Rusel D, Ndontsa, Blanche Laure, Bitchagno, Gabin Thierry M, Mbouangouere, Roukayatou, Lenta, Bruno N, Sewald, Norbert, Tane, Pierre, Tene, Mathieu, and Ngouela, Silvere Augustin. 2021. “Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities”. Natural Product Research .
Seumo, A. S., Nanfack, A. R. D., Ndontsa, B. L., Bitchagno, G. T. M., Mbouangouere, R., Lenta, B. N., Sewald, N., Tane, P., Tene, M., and Ngouela, S. A. (2021). Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research .
Seumo, A.S., et al., 2021. Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research .
A.S. Seumo, et al., “Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities”, Natural Product Research , 2021.
Seumo, A.S., Nanfack, A.R.D., Ndontsa, B.L., Bitchagno, G.T.M., Mbouangouere, R., Lenta, B.N., Sewald, N., Tane, P., Tene, M., Ngouela, S.A.: Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities. Natural Product Research . (2021).
Seumo, Amanda Seumo, Nanfack, Arno Rusel D, Ndontsa, Blanche Laure, Bitchagno, Gabin Thierry M, Mbouangouere, Roukayatou, Lenta, Bruno N, Sewald, Norbert, Tane, Pierre, Tene, Mathieu, and Ngouela, Silvere Augustin. “Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities”. Natural Product Research (2021).
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