Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers

Dachwitz S, Scharkowski B, Sewald N (2021)
Chemistry - A European Journal 27(72): 18043-18046.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Mild transition-metal catalysed cross-couplings enable direct functionalisation of biocatalytically halogenated tryptophans with alkyl iodides, representing a new alternative for late-stage derivatisations of halogenated aromatic amino acids. Moreover, this strategy enables a preparation of (homo)tryptophan regioisomers in a simple two-step synthesis using a Pd-catalysed Negishi cross coupling. This method provides access to non-canonical constitutional surrogates of tryptophan, ready for use in peptide synthesis. © 2021 Wiley-VCH GmbH.
Erscheinungsjahr
2021
Zeitschriftentitel
Chemistry - A European Journal
Band
27
Ausgabe
72
Seite(n)
18043-18046
ISSN
1521-3765
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2958716

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Dachwitz S, Scharkowski B, Sewald N. Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers. Chemistry - A European Journal . 2021;27(72):18043-18046.
Dachwitz, S., Scharkowski, B., & Sewald, N. (2021). Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers. Chemistry - A European Journal , 27(72), 18043-18046. https://doi.org/10.1002/chem.202103353
Dachwitz, Steffen, Scharkowski, Bjarne, and Sewald, Norbert. 2021. “Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers”. Chemistry - A European Journal 27 (72): 18043-18046.
Dachwitz, S., Scharkowski, B., and Sewald, N. (2021). Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers. Chemistry - A European Journal 27, 18043-18046.
Dachwitz, S., Scharkowski, B., & Sewald, N., 2021. Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers. Chemistry - A European Journal , 27(72), p 18043-18046.
S. Dachwitz, B. Scharkowski, and N. Sewald, “Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers”, Chemistry - A European Journal , vol. 27, 2021, pp. 18043-18046.
Dachwitz, S., Scharkowski, B., Sewald, N.: Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers. Chemistry - A European Journal . 27, 18043-18046 (2021).
Dachwitz, Steffen, Scharkowski, Bjarne, and Sewald, Norbert. “Negishi cross-coupling provides alkylated tryptophans and tryptophan regioisomers”. Chemistry - A European Journal 27.72 (2021): 18043-18046.
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2022-07-04T12:47:10Z
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