From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis

Lauxmann MA, Vazquez DS, Schilbert H, Neubauer PR, Lammers KM, Dodero VI (2021)
BioEssays: 2100101.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Lauxmann, Martin A.; Vazquez, Diego S.; Schilbert, HannaUniBi; Neubauer, Pia R.; Lammers, Karen M.; Dodero, Veronica I.
Abstract / Bemerkung
Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several diseases like celiac disease (CeD). The polyQ gliadin fragment binds to the CXCR3 chemokine receptor that activates zonulin upregulation, leading to increased intestinal permeability in humans. Here, we report a general hypothesis based on the structural connection between the polyQ sequence of the immunogenic CeD protein, gliadin, and enteric coccidian parasites proteins. Firstly, a novel interaction pathway between the parasites and the host is described based on the structural similarities between polyQ gliadin fragments and the parasite proteins. Secondly, a potential connection between coccidial infections as a novel environmental trigger of CeD is hypothesized. Therefore, this report represents a promising breakthrough for coccidian research and points out the potential role of coccidian parasites as a novel trigger of CeD that might define a preventive strategy for gluten-related disorders in general.
Erscheinungsjahr
2021
Zeitschriftentitel
BioEssays
Art.-Nr.
2100101
ISSN
0265-9247
eISSN
1521-1878
Page URI
https://pub.uni-bielefeld.de/record/2958645

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Lauxmann MA, Vazquez DS, Schilbert H, Neubauer PR, Lammers KM, Dodero VI. From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis. BioEssays. 2021: 2100101.
Lauxmann, M. A., Vazquez, D. S., Schilbert, H., Neubauer, P. R., Lammers, K. M., & Dodero, V. I. (2021). From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis. BioEssays, 2100101. https://doi.org/10.1002/bies.202100101
Lauxmann, M. A., Vazquez, D. S., Schilbert, H., Neubauer, P. R., Lammers, K. M., and Dodero, V. I. (2021). From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis. BioEssays:2100101.
Lauxmann, M.A., et al., 2021. From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis. BioEssays, : 2100101.
M.A. Lauxmann, et al., “From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis”, BioEssays, 2021, : 2100101.
Lauxmann, M.A., Vazquez, D.S., Schilbert, H., Neubauer, P.R., Lammers, K.M., Dodero, V.I.: From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis. BioEssays. : 2100101 (2021).
Lauxmann, Martin A., Vazquez, Diego S., Schilbert, Hanna, Neubauer, Pia R., Lammers, Karen M., and Dodero, Veronica I. “From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis”. BioEssays (2021): 2100101.
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