Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients

Wille K, Huenerbein K, Jagenberg E, Sadjadian P, Becker T, Kolatzki V, Meixner R, Marchi H, Fuchs C, Griesshammer M (2021)
European Journal of Haematology.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Wille, Kai; Huenerbein, Karlo; Jagenberg, Ellen; Sadjadian, Parvis; Becker, Tatjana; Kolatzki, Vera; Meixner, Raphael; Marchi, HannahUniBi ; Fuchs, ChristianeUniBi ; Griesshammer, Martin
Abstract / Bemerkung
In patients with bcr-abl-negative myeloproliferative neoplasms (MPN), concerns are often raised about the use of anticoagulants because of an increased bleeding risk. However, there are few MPN studies focusing on bleeding. To investigate bleeding complications in MPN, we report our retrospective, single-center study of 829 patients with a median follow-up of 5.5years (range: 0.1-35.6). A first bleeding event occurred in 143 of 829 patients (17.2%), corresponding to an incidence rate of 2.29% per patient/year. During the follow-up period, one out of 829 patients (0.1%) died due to bleeding. Regarding anticoagulation, most bleeding occurred in patients on antiplatelet therapies (60.1%), followed by patients on anticoagulation therapies (20.3%) and patients not on anticoagulation (19.6%). In multivariate analysis, administration of antiplatelet (HR 2.31 [1.43, 3.71]) and anticoagulation therapies (HR 4.06 [2.32, 7.09]), but not age, gender or mutation status, was associated with an increased bleeding risk. Comparing the "probability of bleeding-free survival" between the MPN subtypes, no significant difference was observed (p=0.91, log-rank test). Our retrospective study shows that antiplatelet and anticoagulation therapies significantly increase the risk of bleeding in MPN patients without affecting mortality. However, there is no reason to refrain from guideline-conform primary or secondary anticoagulation in MPN patients. © 2021 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
Erscheinungsjahr
2021
Zeitschriftentitel
European Journal of Haematology
eISSN
1600-0609
Page URI
https://pub.uni-bielefeld.de/record/2958644

Zitieren

Wille K, Huenerbein K, Jagenberg E, et al. Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients. European Journal of Haematology. 2021.
Wille, K., Huenerbein, K., Jagenberg, E., Sadjadian, P., Becker, T., Kolatzki, V., Meixner, R., et al. (2021). Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients. European Journal of Haematology. https://doi.org/10.1111/ejh.13721
Wille, K., Huenerbein, K., Jagenberg, E., Sadjadian, P., Becker, T., Kolatzki, V., Meixner, R., Marchi, H., Fuchs, C., and Griesshammer, M. (2021). Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients. European Journal of Haematology.
Wille, K., et al., 2021. Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients. European Journal of Haematology.
K. Wille, et al., “Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients”, European Journal of Haematology, 2021.
Wille, K., Huenerbein, K., Jagenberg, E., Sadjadian, P., Becker, T., Kolatzki, V., Meixner, R., Marchi, H., Fuchs, C., Griesshammer, M.: Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients. European Journal of Haematology. (2021).
Wille, Kai, Huenerbein, Karlo, Jagenberg, Ellen, Sadjadian, Parvis, Becker, Tatjana, Kolatzki, Vera, Meixner, Raphael, Marchi, Hannah, Fuchs, Christiane, and Griesshammer, Martin. “Bleeding complications in bcr-abl negative myeloproliferative neoplasms (MPN): a retrospective single-center study of 829 MPN patients”. European Journal of Haematology (2021).

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 34719056
PubMed | Europe PMC

Suchen in

Google Scholar