Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity

Chouna HSD, Bankeu JJK, Fongang YSF, Dize D, Ponou BK, Bitchagno GTM, Awantu AF, Lenta BN, Fekam FB, Ngouela SA, Opatz T, et al. (2021)
PHYTOCHEMISTRY LETTERS 41: 14-20.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Chouna, Hardo Suzy Donfack; Bankeu, Jean Jules Kezetas; Fongang, Yannick Stephane Fotsing; Dize, Darline; Ponou, Beaudelaire Kemvoufo; Bitchagno, Gabin Thierry Mbahbou; Awantu, Angelbert Fusi; Lenta, Bruno Ndjakou; Fekam, Fabrice Boyom; Ngouela, Silvere Augustin; Opatz, Till; Sewald, NorbertUniBi
Alle
Abstract / Bemerkung
The investigation of the CH2Cl2-MeOH (1:1) extract of Peperomia vulcanica which showed antileishmanial activity during preliminary screening led to the isolation of two previously unknown compounds named peperolignan (1) and peperotannin (2) along with 13 known compounds. Their structures were determined on the basis of their spectroscopic data. The isolated compounds were assessed in vitro for their antileishmanial and antiplasmodial activities against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and the Plasmodium falciparum chloroquine-sensitive 3D7 strain (Pf3D7), respectively. They were also assessed for their cytotoxicity on Raw 264.7 macrophage cells. The mixture of 4-hydroxy-2[(3,4-methylenedioxyphenyl)nonanoyl)cyclo-hexan-1,3-dione and 4-hydroxy-2[(3,4-methylenedioxyphenyl) undecanoyl] cyclo-hexane-1,3-dione (10a and 10b) exhibited potent antiplasmodial activity (IC50 = 0.35 mu g/mL) with selectivity index higher than 10-fold (SI = 63.4) and moderate leishmanicidal activity (IC50 = 12.17 mu g/mL) with very low selectivity index (SI = 1.82). The obtained results could provide an extent of validation to the traditional uses of Peperomia vulcanica for the treatment of malaria in endemic areas.
Stichworte
Piperaceae; Peperomia vulcania; Peperolignan; Peperotannin; Antileishmanial; Antiplasmodial
Erscheinungsjahr
2021
Zeitschriftentitel
PHYTOCHEMISTRY LETTERS
Band
41
Seite(n)
14-20
eISSN
1874-3900
Page URI
https://pub.uni-bielefeld.de/record/2958151

Zitieren

Chouna HSD, Bankeu JJK, Fongang YSF, et al. Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity. PHYTOCHEMISTRY LETTERS. 2021;41:14-20.
Chouna, H. S. D., Bankeu, J. J. K., Fongang, Y. S. F., Dize, D., Ponou, B. K., Bitchagno, G. T. M., Awantu, A. F., et al. (2021). Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity. PHYTOCHEMISTRY LETTERS, 41, 14-20. https://doi.org/10.1016/j.phytol.2020.10.010
Chouna, H. S. D., Bankeu, J. J. K., Fongang, Y. S. F., Dize, D., Ponou, B. K., Bitchagno, G. T. M., Awantu, A. F., Lenta, B. N., Fekam, F. B., Ngouela, S. A., et al. (2021). Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity. PHYTOCHEMISTRY LETTERS 41, 14-20.
Chouna, H.S.D., et al., 2021. Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity. PHYTOCHEMISTRY LETTERS, 41, p 14-20.
H.S.D. Chouna, et al., “Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity”, PHYTOCHEMISTRY LETTERS, vol. 41, 2021, pp. 14-20.
Chouna, H.S.D., Bankeu, J.J.K., Fongang, Y.S.F., Dize, D., Ponou, B.K., Bitchagno, G.T.M., Awantu, A.F., Lenta, B.N., Fekam, F.B., Ngouela, S.A., Opatz, T., Sewald, N.: Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity. PHYTOCHEMISTRY LETTERS. 41, 14-20 (2021).
Chouna, Hardo Suzy Donfack, Bankeu, Jean Jules Kezetas, Fongang, Yannick Stephane Fotsing, Dize, Darline, Ponou, Beaudelaire Kemvoufo, Bitchagno, Gabin Thierry Mbahbou, Awantu, Angelbert Fusi, Lenta, Bruno Ndjakou, Fekam, Fabrice Boyom, Ngouela, Silvere Augustin, Opatz, Till, and Sewald, Norbert. “Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity”. PHYTOCHEMISTRY LETTERS 41 (2021): 14-20.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Suchen in

Google Scholar