DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers

Carleial S, Natt D, Unternaehrer E, Elbert T, Robjant K, Wilker S, Vukojevic V, Kolassa I-T, Zeller AC, Koebach A (2021)
SCIENTIFIC REPORTS 11: 18493.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Carleial, Samuel; Natt, Daniel; Unternaehrer, Eva; Elbert, Thomas; Robjant, Katy; Wilker, SarahUniBi; Vukojevic, Vanja; Kolassa, Iris-Tatjana; Zeller, Anja C.; Koebach, Anke
Abstract / Bemerkung
The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group design, we examined methylome-wide changes in saliva samples of 84 female former child soldiers from Eastern DR Congo before and six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM, RIPOR2, AFAP1 and MOCOS. In addition, treatment associations overlapped at gene level with baseline clinical and social outcomes. Treatment related DMPs are involved in memory formation-the key agent in trauma focused treatments-and enriched for molecular pathways commonly affected by trauma related disorders. Results were partially replicated in an independent sample of 53 female former child soldiers from Northern Uganda. Our results suggest a molecular impact of psychological treatment in women with war-related childhood trauma.
Erscheinungsjahr
2021
Zeitschriftentitel
SCIENTIFIC REPORTS
Band
11
Art.-Nr.
18493
eISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2958150

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Carleial S, Natt D, Unternaehrer E, et al. DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. SCIENTIFIC REPORTS. 2021;11: 18493.
Carleial, S., Natt, D., Unternaehrer, E., Elbert, T., Robjant, K., Wilker, S., Vukojevic, V., et al. (2021). DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. SCIENTIFIC REPORTS, 11, 18493. https://doi.org/10.1038/s41598-021-98067-9
Carleial, S., Natt, D., Unternaehrer, E., Elbert, T., Robjant, K., Wilker, S., Vukojevic, V., Kolassa, I. - T., Zeller, A. C., and Koebach, A. (2021). DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. SCIENTIFIC REPORTS 11:18493.
Carleial, S., et al., 2021. DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. SCIENTIFIC REPORTS, 11: 18493.
S. Carleial, et al., “DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers”, SCIENTIFIC REPORTS, vol. 11, 2021, : 18493.
Carleial, S., Natt, D., Unternaehrer, E., Elbert, T., Robjant, K., Wilker, S., Vukojevic, V., Kolassa, I.-T., Zeller, A.C., Koebach, A.: DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. SCIENTIFIC REPORTS. 11, : 18493 (2021).
Carleial, Samuel, Natt, Daniel, Unternaehrer, Eva, Elbert, Thomas, Robjant, Katy, Wilker, Sarah, Vukojevic, Vanja, Kolassa, Iris-Tatjana, Zeller, Anja C., and Koebach, Anke. “DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers”. SCIENTIFIC REPORTS 11 (2021): 18493.

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